H
Henk M. De Feyter
Researcher at Yale University
Publications - 47
Citations - 2086
Henk M. De Feyter is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 18, co-authored 40 publications receiving 1494 citations. Previous affiliations of Henk M. De Feyter include Eindhoven University of Technology.
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Journal ArticleDOI
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
Parker L. Sulkowski,Christopher D. Corso,Nathaniel D. Robinson,Susan E. Scanlon,Karin Purshouse,Hanwen Bai,Yanfeng Liu,Ranjini K. Sundaram,Denise C. Hegan,Nathan R. Fons,Gregory A. Breuer,Yuanbin Song,Ketu Mishra-Gorur,Henk M. De Feyter,Robin A. de Graaf,Yulia V. Surovtseva,Maureen Kachman,Stephanie Halene,Murat Gunel,Peter M. Glazer,Ranjit S. Bindra +20 more
TL;DR: It is reported that IDH1/2 mutations induce a homologous recombination defect that renders tumor cells exquisitely sensitive to poly(adenosine 5′-diphosphate–ribose) polymerase (PARP) inhibitors, and an unexpected link between oncometabolites, altered DNA repair, and genetic instability is uncovered.
Journal ArticleDOI
13C MRS studies of neuroenergetics and neurotransmitter cycling in humans.
TL;DR: The current state of 13 C MRS as it is applied to the study of neuroenergetics and neurotransmitter cycling in humans is reviewed, predominantly on recent findings in humans regarding metabolic pathways, applications to clinical research and the technical status of the method.
Journal ArticleDOI
Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo
Henk M. De Feyter,Kevin L. Behar,Zachary Corbin,Robert K. Fulbright,Peter B. Brown,Scott McIntyre,Terence W. Nixon,Douglas L. Rothman,Robin A. de Graaf +8 more
TL;DR: Deuterium metabolic imaging is a novel, noninvasive approach that combines deuterium magnetic resonance spectroscopic imaging with oral intake or intravenous infusion of nonradioactive 2H-labeled substrates to generate three-dimensional metabolic maps that reveal glucose metabolism beyond mere uptake.
Journal ArticleDOI
Glutamate metabolism in major depressive disorder
Chadi G. Abdallah,Lihong Jiang,Henk M. De Feyter,Madonna K. Fasula,John H. Krystal,Douglas L. Rothman,Graeme F. Mason,Gerard Sanacora +7 more
TL;DR: Signs of a specific form of glutamate-related dysfunction that could be targeted by novel therapies were found using novel, state-of-the-art techniques to address this issue.
Journal ArticleDOI
The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects.
Chadi G. Abdallah,Chadi G. Abdallah,Henk M. De Feyter,Lynnette A. Averill,Lynnette A. Averill,Lihong Jiang,Christopher L. Averill,Christopher L. Averill,Golam M. I. Chowdhury,Prerana Purohit,Prerana Purohit,Robin A. de Graaf,Irina Esterlis,Irina Esterlis,Christoph Juchem,Brian Pittman,John H. Krystal,John H. Krystal,Douglas L. Rothman,Gerard Sanacora,Gerard Sanacora,Graeme F. Mason +21 more
TL;DR: These findings provide the most direct evidence in humans to date that ketamine increases glutamate release in the prefrontal cortex, a mechanism previously linked to schizophrenia pathophysiology and implicated in the induction of rapid antidepressant effects.