K
Karin Purshouse
Researcher at Edinburgh Cancer Research Centre
Publications - 32
Citations - 2133
Karin Purshouse is an academic researcher from Edinburgh Cancer Research Centre. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 9, co-authored 27 publications receiving 1314 citations. Previous affiliations of Karin Purshouse include Imperial College London & University of Oxford.
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Journal ArticleDOI
COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study.
Lennard Y W Lee,Jean-Baptiste Cazier,Vasileios Angelis,Roland Arnold,Vartika Bisht,Naomi A. Campton,Julia Chackathayil,Vinton Cheng,Helen Curley,Matthew W. Fittall,Luke Freeman-Mills,Spyridon Gennatas,Anshita Goel,Simon Hartley,D.J. Hughes,David J. Kerr,Alvin J.X. Lee,Rebecca Lee,Sophie McGrath,Christopher P. Middleton,N. Murugaesu,Thomas Newsom-Davis,Alicia Okines,Anna Olsson-Brown,Claire Palles,Yi Pan,Ruth Pettengell,Thomas Powles,Emily A. Protheroe,Karin Purshouse,Archana Sharma-Oates,Shivan Sivakumar,Ashley J. Smith,Thomas Starkey,Chris D. Turnbull,Csilla Várnai,Nadia Yousaf,Rachel Kerr,Gary Middleton +38 more
TL;DR: The clinical and demographic characteristics and COVID-19 outcomes in patients with cancer appear to be principally driven by age, gender, and comorbidities.
Journal ArticleDOI
COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study.
Lee Lyw.,Cazier J-B.,Thomas Starkey,Briggs Sew.,Roland Arnold,Vartika Bisht,Stephen Booth,Naomi A. Campton,Cheng Vwt.,Gary S. Collins,Helen Curley,P Earwaker,Matthew W. Fittall,Spyridon Gennatas,Anshita Goel,Simon Hartley,D.J. Hughes,David J. Kerr,Lee Ajx.,Rebecca Lee,Siow Ming Lee,H Mckenzie,Christopher P. Middleton,N. Murugaesu,Thomas Newsom-Davis,Anna Olsson-Brown,Claire Palles,Thomas Powles,Emily A. Protheroe,Karin Purshouse,Archana Sharma-Oates,Shivan Sivakumar,A J Smith,O Topping,Chris D. Turnbull,Csilla Várnai,Briggs Adm.,Gary Middleton,Rachel Kerr +38 more
TL;DR: This study compared adult patients with cancer enrolled in the UK Coronavirus Cancer Monitoring Project between March 18 and May 8, 2020 with a parallel non-COVID-19 UK cancer control population, and analyzed the effect of primary tumour subtype, age, and sex and on severe acute respiratory syndrome coronavirus 2 prevalence and the case–fatality rate during hospital admission.
Journal ArticleDOI
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.
Parker L. Sulkowski,Christopher D. Corso,Nathaniel D. Robinson,Susan E. Scanlon,Karin Purshouse,Hanwen Bai,Yanfeng Liu,Ranjini K. Sundaram,Denise C. Hegan,Nathan R. Fons,Gregory A. Breuer,Yuanbin Song,Ketu Mishra-Gorur,Henk M. De Feyter,Robin A. de Graaf,Yulia V. Surovtseva,Maureen Kachman,Stephanie Halene,Murat Gunel,Peter M. Glazer,Ranjit S. Bindra +20 more
TL;DR: It is reported that IDH1/2 mutations induce a homologous recombination defect that renders tumor cells exquisitely sensitive to poly(adenosine 5′-diphosphate–ribose) polymerase (PARP) inhibitors, and an unexpected link between oncometabolites, altered DNA repair, and genetic instability is uncovered.
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The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer
L L da Motta,L L da Motta,L L da Motta,Ioanna Ledaki,Karin Purshouse,Shozeb Haider,M A De Bastiani,Dilair Baban,Matteo Morotti,Graham Steers,Simon Wigfield,Esther Bridges,J-L Li,J-L Li,Stefan Knapp,Stefan Knapp,Daniel Ebner,Fábio Klamt,Adrian L. Harris,Alan McIntyre,Alan McIntyre +20 more
TL;DR: It is identified that BETi dually targets angiogenesis and the hypoxic response, an effective combination at reducing tumour growth in preclinical studies.
Journal ArticleDOI
The UK Coronavirus Cancer Monitoring Project: protecting patients with cancer in the era of COVID-19
Iris Anil,Roland Arnold,Sam Benkwitz-Beford,Simon Branford,Naomi A. Campton,Jean-Baptiste Cazier,Vinton Cheng,Helen Curley,Jamie J. D’Costa,Andrew Edmondson,Anshita Goel,Simon Hartley,D.J. Hughes,Rachel Kerr,Alvin J.X. Lee,Lennard Y W Lee,Naomi Longworth,Christopher P. Middleton,Gary Middleton,Piangfan Naksukpaiboon,Anna Olsson-Brown,Claire Palles,Karin Purshouse,Carol Sandys,Archana Sharma-Oates,Shivan Sivakumar,Ashley Wilder Smith,Thomas Starkey,Simon Thompson,Csilla Várnai +29 more