Henning W. Zimmermann

TL;DR: Hepatic macrophages are central in the pathogenesis of chronic liver injury and have been proposed as potential targets in combatting fibrosis, and understanding the mechanisms that regulate hepaticmacrophage heterogeneity may help to develop novel macrophage subset-targeted therapies for Liver injury and fibrosis.

TL;DR: The data indicate that miR‐29 mediates the regulation of liver fibrosis and is part of a signaling nexus involving TGF‐β‐ and NF‐κB–dependent down‐regulation of miR-29 family members in HSC with subsequent up‐ regulation of extracellular matrix genes.

TL;DR: Subpopulations of infiltrating monocytes in acute and chronic carbon tetrachloride‐induced liver injury in mice are characterized and inflammatory Gr1+ monocytes, recruited into the injured liver via CCR2‐dependent bone marrow egress, promote the progression of liver fibrosis.

TL;DR: This study demonstrates dynamic changes of circulating monocytes during ageing in humans, and suggests the expansion of the non-classical CD14+CD16+ subtype, alterations of surface protein and chemokine receptor expression as well as circulating monocyte-related chemokines possibly contribute to the preserved functionality of the monocyte pool throughout adulthood.

TL;DR: The expansion of CD14+CD16+ monocytes in the circulation and liver of CLD-patients upon disease progression is demonstrated and their functional contribution to the perpetuation of intrahepatic inflammation and profibrogenic HSC activation in liver cirrhosis is suggested.