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Kira Bettermann
Researcher at Otto-von-Guericke University Magdeburg
Publications - 6
Citations - 1093
Kira Bettermann is an academic researcher from Otto-von-Guericke University Magdeburg. The author has contributed to research in topics: Signal transduction & IκB kinase. The author has an hindex of 4, co-authored 6 publications receiving 992 citations. Previous affiliations of Kira Bettermann include RWTH Aachen University.
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Journal ArticleDOI
Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis
Christoph Roderburg,Gerd-Willem Urban,Kira Bettermann,Mihael Vucur,Henning W. Zimmermann,Sabine Schmidt,Jörn Janssen,Christiane Koppe,Percy A. Knolle,Mirco Castoldi,Mirco Castoldi,Frank Tacke,Christian Trautwein,Tom Luedde +13 more
TL;DR: The data indicate that miR‐29 mediates the regulation of liver fibrosis and is part of a signaling nexus involving TGF‐β‐ and NF‐κB–dependent down‐regulation of miR-29 family members in HSC with subsequent up‐ regulation of extracellular matrix genes.
Journal ArticleDOI
TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.
Kira Bettermann,Mihael Vucur,Johannes Haybaeck,Christiane Koppe,Jörn Janssen,Felix Heymann,Achim Weber,Ralf Weiskirchen,Christian Liedtke,Nikolaus Gassler,Michael Müller,Rita Vos,Monika Julia Wolf,Yannick Boege,Gitta Maria Seleznik,Nicolas Zeller,Daniel Erny,Thomas J. Fuchs,Stefan Zoller,Stefano Cairo,Marie-Annick Buendia,Marco Prinz,Shizuo Akira,Frank Tacke,Mathias Heikenwalder,Christian Trautwein,Tom Luedde +26 more
TL;DR: Conditional ablation of TAK1 in liver parenchymal cells causes hepatocyte dysplasia and early-onset hepatocarcinogenesis, coinciding with biliary ductopenia and cholestasis and serves as a gatekeeper for a protumorigenic, NF-kappaB-independent function of NEMO in parenChymal liver cells.
Journal ArticleDOI
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development
Yannick Boege,Mohsen Malehmir,Marc E. Healy,Kira Bettermann,Anna Lorentzen,Mihael Vucur,Akshay K. Ahuja,Friederike Böhm,Joachim C. Mertens,Yutaka Shimizu,Lukas Frick,Caroline Remouchamps,Karun Mutreja,Thilo Kähne,Devakumar Sundaravinayagam,Monika Julia Wolf,Hubert Rehrauer,Christiane Koppe,Tobias Speicher,Susagna Padrissa-Altés,Renaud Maire,Jörn M. Schattenberg,Ju-Seong Jeong,Lei Liu,Stefan Zwirner,Stefan Zwirner,RJ Boger,Norbert Hüser,Roger J. Davis,Beat Müllhaupt,Holger Moch,Henning Schulze-Bergkamen,Pierre-Alain Clavien,Sabine Werner,Lubor Borsig,Sanjiv A. Luther,Philipp J. Jost,Ricardo Weinlich,Kristian Unger,Axel Behrens,Laura K. Hillert,Christopher P. Dillon,Michela Di Virgilio,David Wallach,Emmanuel Dejardin,Lars Zender,Lars Zender,Michael Naumann,Henning Walczak,Douglas R. Green,Massimo Lopes,Inna N. Lavrik,Tom Luedde,Mathias Heikenwalder,Mathias Heikenwalder,Achim Weber +55 more
TL;DR: This work mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated DNA damage through DNA damage-sensing mechanism in hepatocytes.
Journal ArticleDOI
Mouse models of hepatocarcinogenesis: What can we learn for the prevention of human hepatocellular carcinoma?
Mihael Vucur,Christoph Roderburg,Kira Bettermann,Frank Tacke,Mathias Heikenwalder,Christian Trautwein,Tom Luedde +6 more
TL;DR: A new genetic mouse model for HCC is discussed, the liver-specific TAK1 knockout mouse, which lacks the NF-&κB activating kinase TAK 1 specifically in parenchymal liver cells.