C
Christoph Roderburg
Researcher at University of Düsseldorf
Publications - 241
Citations - 6217
Christoph Roderburg is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 33, co-authored 164 publications receiving 4575 citations. Previous affiliations of Christoph Roderburg include Charité & Humboldt University of Berlin.
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Journal ArticleDOI
Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis
Christoph Roderburg,Gerd-Willem Urban,Kira Bettermann,Mihael Vucur,Henning W. Zimmermann,Sabine Schmidt,Jörn Janssen,Christiane Koppe,Percy A. Knolle,Mirco Castoldi,Mirco Castoldi,Frank Tacke,Christian Trautwein,Tom Luedde +13 more
TL;DR: The data indicate that miR‐29 mediates the regulation of liver fibrosis and is part of a signaling nexus involving TGF‐β‐ and NF‐κB–dependent down‐regulation of miR-29 family members in HSC with subsequent up‐ regulation of extracellular matrix genes.
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Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study.
Philipp Jungebluth,Philipp Jungebluth,Evren Alici,Silvia Baiguera,Pontus Blomberg,Béla Bozóky,Claire Crowley,Oskar Einarsson,Tomas Gudbjartsson,Sylvie Le Guyader,Gert Henriksson,Ola Hermanson,Jan Erik Juto,Bertil Leidner,Bertil Leidner,Tobias Lilja,Jan Liska,Tom Luedde,Vanessa Lundin,Guido Moll,Christoph Roderburg,Staffan Strömblad,Tolga Sutlu,Emma Watz,Emma Watz,Alexander M. Seifalian,Paolo Macchiarini,Paolo Macchiarini +27 more
TL;DR: These findings, together with increased levels of regenerative-associated plasma factors, strongly suggest stem-cell homing and cell-mediated wound repair, extracellular matrix remodelling, and neovascularisation of the graft are key factors for successful clinical outcome.
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RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction
Mark Luedde,Matthias Lutz,Natalie Carter,Justyna Sosna,Christoph Jacoby,Mihael Vucur,Jérémie Gautheron,Christoph Roderburg,Nadine Borg,Florian Reisinger,Hans-Joerg Hippe,Andreas Linkermann,Monika Julia Wolf,Stefan Rose-John,Renate Lüllmann-Rauch,Dieter Adam,Ulrich Flögel,Mathias Heikenwalder,Tom Luedde,Norbert Frey +19 more
TL;DR: It is shown that RIP3-dependent necroptosis modulates post-ischaemic adverse remodelling in a mouse model of MI, and this novel signalling pathway may be an attractive target for future therapies that aim to limit the adverse consequences of myocardial ischaemia.
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A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis
Jérémie Gautheron,Mihael Vucur,Florian Reisinger,David Vargas Cardenas,Christoph Roderburg,Christiane Koppe,Karina Kreggenwinkel,Anne T. Schneider,Matthias Bartneck,Ulf P. Neumann,Ali Canbay,Helen L. Reeves,Mark Luedde,Frank Tacke,Christian Trautwein,Mathias Heikenwalder,Tom Luedde +16 more
TL;DR: It is shown that RIP3 is upregulated in human NASH and in a dietary mouse model of steatohepatitis, and this pathway might represent a novel and specific target for pharmacological strategies in patients with NASH.
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miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1
Christian L. Lino Cardenas,Imène Sarah Henaoui,Imène Sarah Henaoui,Elisabeth Courcot,Christoph Roderburg,Christelle Cauffiez,Sébastien Aubert,Sébastien Aubert,Marie-Christine Copin,Marie-Christine Copin,Benoit Wallaert,François Glowacki,Edmone Dewaeles,Jadranka Milosevic,Julien Maurizio,Julien Maurizio,John Tedrow,Brice Marcet,Brice Marcet,Jean-Marc Lo-Guidice,Naftali Kaminski,Pascal Barbry,Pascal Barbry,Tom Luedde,Michael Perrais,Michael Perrais,Bernard Mari,Bernard Mari,Nicolas Pottier +28 more
TL;DR: MiR-199a-5p behaves as a major regulator of tissue fibrosis with therapeutic potency to treat fibroproliferative diseases and is a key effector of TGFβ signaling in lung fibroblasts by regulating CAV1, a critical mediator of pulmonary fibrosis.