Henriette Rudolph

TL;DR: This review illustrates examples of established brain barrier models, in which the specific reaction patterns of different viral families can be analyzed, and highlights the pathogen specific array of cytokines and chemokines involved in immunological responses in viral CNS infections.

TL;DR: Improved molecular typing and several EV surveillance programs (primarily geared toward the detection of poliovirus outbreaks) have led to higher detection rates of enteroviral infections worldwide.

TL;DR: Analysis of the cellular and molecular mechanisms involved in the migration of different human CD4+ T-cell subsets across the BBB versus the BCSFB indicates that different Th subsets may use different anatomical routes to enter the CNS during immune surveillance versus neuroinflammation.

TL;DR: In vitro live cell imaging directly compared the multistep extravasation of activated CD4+ and CD8+ T cells across primary mouse brain microvascular endothelial cells (pMBMECs) as a model for the blood–brain barrier (BBB) under physiological flow to establish cellular and molecular mechanisms distinguishable from those involved for CD4- T cells.

TL;DR: It is presumed that the choroid plexus might be an underestimated site of CNS invasion, since neuroblastoma cell lines are able to actively cross a choroids plexUS epithelial cell layer.