Martin März

TL;DR: It is presumed that the choroid plexus might be an underestimated site of CNS invasion, since neuroblastoma cell lines are able to actively cross a choroids plexUS epithelial cell layer.

TL;DR: This work presents a unique in vitro BCSFB model suitable to study CNS invasion of lymphoblasts in a human setting, providing the opportunity to investigate experimental variables, which may determine CNS disease childhood ALL.

TL;DR: A method is described that allows the detection of activated (GTP‐bound) Rho in fixed Xenopus tissue using a fusion protein of Rhotekin and Green‐Fluorescent‐Protein (RBD‐GFP), which is produced in bacteria and can be purified biochemically.

TL;DR: A porcine in vitro model of the blood-cerebrospinal fluid barrier based on choroid plexus epithelial cells was optimized for culture on cell culture filter inserts to prevent growth of the cells through filter pores, and retained barrier function and allowed improved investigation of porcines granulocyte transmigration across the cell layer.

TL;DR: In this article, a microfluidic system based on transparent biocompatible polymers with a porous membrane as substrate for various cell types was presented, which allows the simulation of various physiological barriers under continuous laminar flow conditions at distinct tunable shear rates.