M
Matthias Dürken
Researcher at Heidelberg University
Publications - 25
Citations - 4078
Matthias Dürken is an academic researcher from Heidelberg University. The author has contributed to research in topics: Medicine & Choroid plexus. The author has an hindex of 13, co-authored 22 publications receiving 3464 citations. Previous affiliations of Matthias Dürken include University of Mannheim.
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Journal ArticleDOI
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Jeremy Schwartzentruber,Andrey Korshunov,Xiaoyang Liu,David T.W. Jones,Elke Pfaff,Karine Jacob,Dominik Sturm,Adam M. Fontebasso,Dong Anh Khuong Quang,Martje Tönjes,Volker Hovestadt,Steffen Albrecht,Marcel Kool,André Nantel,Carolin Konermann,Anders Lindroth,Natalie Jäger,Tobias Rausch,Marina Ryzhova,Jan O. Korbel,Thomas Hielscher,Peter Hauser,Miklós Garami,Almos Klekner,László Bognár,Martin Ebinger,Martin U. Schuhmann,Wolfram Scheurlen,Arnulf Pekrun,Michael C. Frühwald,Wolfgang Roggendorf,CM Kramm,Matthias Dürken,Jeffrey Atkinson,Pierre Lepage,Alexandre Montpetit,Magdalena Zakrzewska,Krzystof Zakrzewski,Pawel P. Liberski,Zhifeng Dong,Peter M. Siegel,Andreas E. Kulozik,Marc Zapatka,Abhijit Guha,David Malkin,Jörg Felsberg,Guido Reifenberger,Andreas von Deimling,Andreas von Deimling,Koichi Ichimura,V. Peter Collins,Hendrik Witt,Hendrik Witt,Till Milde,Till Milde,Olaf Witt,Olaf Witt,Cindy Zhang,Pedro Castelo-Branco,Peter Lichter,Damien Faury,Uri Tabori,Christoph Plass,Jacek Majewski,Stefan M. Pfister,Stefan M. Pfister,Nada Jabado +66 more
TL;DR: The presence of H3F3A/ATRX-DAXX/TP53 mutations was strongly associated with alternative lengthening of telomeres and specific gene expression profiles, suggesting that defects of the chromatin architecture underlie paediatric and young adult GBM pathogenesis.
Journal ArticleDOI
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.
Dominik Sturm,Hendrik Witt,Hendrik Witt,Volker Hovestadt,Dong Anh Khuong-Quang,David T.W. Jones,Carolin Konermann,Elke Pfaff,Martje Tönjes,Martin Sill,Sebastian Bender,Marcel Kool,Marc Zapatka,Natalia Becker,Manuela Zucknick,Thomas Hielscher,Xiaoyang Liu,Adam M. Fontebasso,Marina Ryzhova,Steffen Albrecht,Karine Jacob,Marietta Wolter,Martin Ebinger,Martin U. Schuhmann,Timothy E. Van Meter,Michael C. Frühwald,Holger Hauch,Arnulf Pekrun,Bernhard Radlwimmer,Tim Niehues,Gregor Von Komorowski,Matthias Dürken,Andreas E. Kulozik,Jenny Madden,Andrew M. Donson,Nicholas K. Foreman,Rachid Drissi,Maryam Fouladi,Wolfram Scheurlen,Andreas von Deimling,Andreas von Deimling,Camelia M. Monoranu,Wolfgang Roggendorf,Christel Herold-Mende,Andreas Unterberg,Christof M. Kramm,Jörg Felsberg,Christian Hartmann,Benedikt Wiestler,Wolfgang Wick,Till Milde,Till Milde,Olaf Witt,Olaf Witt,Anders Lindroth,Jeremy Schwartzentruber,Damien Faury,Adam Fleming,Magdalena Zakrzewska,Pawel P. Liberski,Krzysztof Zakrzewski,Peter Hauser,Miklós Garami,Almos Klekner,László Bognár,Sorana Morrissy,Florence M.G. Cavalli,Michael D. Taylor,Peter van Sluis,Jan Koster,Rogier Versteeg,Richard Volckmann,Tom Mikkelsen,Kenneth Aldape,Guido Reifenberger,V. Peter Collins,Jacek Majewski,Andrey Korshunov,Peter Lichter,Christoph Plass,Nada Jabado,Stefan M. Pfister,Stefan M. Pfister +82 more
TL;DR: It is demonstrated that each H3F3A mutation defines an epigenetic subgroup of GBM with a distinct global methylation pattern, and that they are mutually exclusive with IDH1 mutations, which characterize a third mutation-defined subgroup.
Journal ArticleDOI
Improved 6-year overall survival in AT/RT - results of the registry study Rhabdoid 2007.
Kerstin Bartelheim,Karolina Nemes,Angela Seeringer,Kornelius Kerl,Jochen Buechner,Jochen Buechner,Joachim Boos,Norbert Graf,Matthias Dürken,Joachim Gerss,Martin Hasselblatt,Rolf-Dieter Kortmann,Irene von Luettichau,Inga Nagel,Randi Nygaard,Florian Oyen,Eduardo Quiroga,Paul-Gerhardt Schlegel,Irene Schmid,Reinhard Schneppenheim,Reiner Siebert,Palma Solano-Paez,Beate Timmermann,Monika Warmuth-Metz,Michael C. Frühwald +24 more
TL;DR: Although the analysis is biased due to heterogeneous adherence to therapy, EU‐RHAB provides the best available basis for phase I/II clinical trials.
Journal ArticleDOI
Detection of Aspergillus DNA by a nested PCR assay is able to improve the diagnosis of invasive aspergillosis in paediatric patients
Margit Hummel,Birgit Spiess,Julia Roder,Gregor von Komorowski,Matthias Dürken,Karim Kentouche,Hans J. Laws,Handan Mörz,Ruediger Hehlmann,Dieter Buchheidt +9 more
TL;DR: The authors' nested PCR assay was able to detect Aspergillus DNA in blood, cerebrospinal fluid and bronchoalveolar lavage samples from paediatric and adolescent patients with IA with high sensitivity and specificity rates.
Journal ArticleDOI
Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.
Elke Pfaff,Ahmed El Damaty,Ahmed El Damaty,Gnana Prakash Balasubramanian,Mirjam Blattner-Johnson,Barbara C. Worst,Sebastian Stark,Hendrik Witt,Kristian W. Pajtler,Cornelis M. van Tilburg,Cornelis M. van Tilburg,Ruth Witt,Till Milde,Martin Jakobs,Petra Fiesel,Petra Fiesel,Michael C. Frühwald,Pablo Hernáiz Driever,Ulrich W. Thomale,Martin U. Schuhmann,Markus Metzler,Konrad Bochennek,Thorsten Simon,Matthias Dürken,Michael Karremann,Stephanie Knirsch,Martin Ebinger,André O. von Bueren,Torsten Pietsch,Christel Herold-Mende,David E. Reuss,Karl L. Kiening,Peter Lichter,Angelika Eggert,Angelika Eggert,Christof M. Kramm,Stefan M. Pfister,David T.W. Jones,Heidi Bächli,Olaf Witt +39 more
TL;DR: Brainstem biopsy of DIPG was feasible and yielded sufficient material for comprehensive molecular profiling, and relevant molecular targets were identified impacting clinical management in a substantial subset.