Henry J. George

TL;DR: The identification of this protease provides a specific target for the development of therapeutics to prevent cartilage degradation in arthritis.

TL;DR: A novel disintegrin metalloproteinase with thrombospondin motifs that possesses aggrecanase activity is identified and cloned, which has extensive homology to ADAMTS4 (aggrecanases-1) and the inflammation-associated gene ADAMts1, which is hypothesized to play a pivotal role in cartilage damage.

TL;DR: The proportion of patients carrying NNRTI resistance mutations, usually K103N, increased dramatically at the time of initial viral load rebound in cases of treatment failure after exposure to efavirenz, and accumulated more slowly following the emergence of K103n mutant viruses.

TL;DR: Human fibroblast activation protein (FAP), an integral membrane serine protease, was produced in insect cells as a hexa-His-tagged protein using a recombinant baculovirus expression system and was shown to have both postprolyl dipeptidyl peptidase and postgelatinase activities.

TL;DR: It is demonstrated that this system is capable of providing high yields of active enzyme for biochemical, biophysical, and pharmacological investigations and Spectroscopic analysis suggests that the recombinant enzyme adopts native-like secondary and tertiary structure.