James M. Trzaskos

TL;DR: The identification of this protease provides a specific target for the development of therapeutics to prevent cartilage degradation in arthritis.

TL;DR: The strong potential of cannabinoids for inducing long-term alterations in hippocampal neurons through the activation of the ERK pathway may be important for the physiological control of synaptic plasticity and for the general effects of THC in the context of drug abuse.

TL;DR: It is suggested that aggrecan plays a protective role in preventing degradation of collagen fibrils, and that an aggre canase inhibitor may impart overall cartilage protection.

TL;DR: Results show that ERK has a minor contribution to the acute locomotor effects of psychostimulants or to the expression of sensitized responses, whereas it is crucial for the acquisition of locomotor sensitization and psychostIMulant-conditioned locomotor response.

TL;DR: It is shown here that COX-2-derived prostaglandins (PGs) are important for uterine vascular permeability and angiogenesis during implantation and decidualization, suggesting that one cause of the failure of these latter processes in Cox-2(−/−) mice is the deregulated vascular events in the absence of COx-2.