R
Robert C. Bruckner
Researcher at Drexel University
Publications - 15
Citations - 1620
Robert C. Bruckner is an academic researcher from Drexel University. The author has contributed to research in topics: Flavin group & Flavoprotein. The author has an hindex of 12, co-authored 15 publications receiving 1567 citations. Previous affiliations of Robert C. Bruckner include Wilmington University.
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Journal ArticleDOI
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
Micky D. Tortorella,Timothy Burn,Michael A. Pratta,Ilgar Abbaszade,Jeannine M. Hollis,Rui-Qin Liu,Stuart A. Rosenfeld,Robert A. Copeland,Carl P. Decicco,Richard Wynn,A. Rockwell,F. Yang,J. L. Duke,Kimberly A. Solomon,Henry J. George,Robert C. Bruckner,Hideaki Nagase,Yoshifumi Itoh,Dawn Ellis,Harold D. Ross,Barbara H. Wiswall,Kathleen Murphy,M.C. Hillman,Gregory Hollis,Robert C. Newton,Ronald L. Magolda,James M. Trzaskos,E. C. Arner +27 more
TL;DR: The identification of this protease provides a specific target for the development of therapeutics to prevent cartilage degradation in arthritis.
Journal ArticleDOI
Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.
Ilgar Abbaszade,Rui-Qin Liu,Fude Yang,Stuart A. Rosenfeld,O. Harold Ross,John Link,Dawn Ellis,Micky D. Tortorella,Michael A. Pratta,Jeannine M. Hollis,Richard Wynn,J. L. Duke,Henry J. George,M.C. Hillman,Kathleen Murphy,Barbara H. Wiswall,Robert A. Copeland,Carl P. Decicco,Robert C. Bruckner,Hideaki Nagase,Yoshifumi Itoh,Robert C. Newton,Ronald L. Magolda,James M. Trzaskos,Gregory Hollis,Elizabeth C. Arner,Timothy Burn +26 more
TL;DR: A novel disintegrin metalloproteinase with thrombospondin motifs that possesses aggrecanase activity is identified and cloned, which has extensive homology to ADAMTS4 (aggrecanases-1) and the inflammation-associated gene ADAMts1, which is hypothesized to play a pivotal role in cartilage damage.
Journal ArticleDOI
Matrix metalloproteinase–activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity
Charles F. Albright,Graciani Nilsa R,Wei Han,Eddy W. Yue,Ross L. Stein,Zhihong Lai,Melody Diamond,Randine Dowling,Lisa C. Grimminger,Shu-Yun Zhang,Davette L. Behrens,Amy L. Musselman,Robert C. Bruckner,Mingzhu Zhang,Xiang Jiang,Daniel Hu,Anne Higley,Dimeo Susan,Maria Rafalski,Sandya Mandlekar,Bruce Car,Swamy Yeleswaram,Andrew M. Stern,Robert A. Copeland,Andrew P. Combs,Steve P. Seitz,George L. Trainor,Rebecca Taub,Pearl S. Huang,Oliff Allen I +29 more
TL;DR: It is shown that MMP-selective conjugates were preferentially metabolized in HT1080 xenografts, relative to heart and plasma, leading to 10-fold increases in the tumor/heart ratio of doxorubicin.
Journal ArticleDOI
Identification of the Oxygen Activation Site in Monomeric Sarcosine Oxidase: Role of Lys265 in Catalysis
TL;DR: The results provide definitive evidence for Lys265 as the site of oxygen activation and show that a single positively charged amino acid residue is entirely responsible for the rate acceleration observed with wild-type enzyme.
Journal ArticleDOI
Probing oxygen activation sites in two flavoprotein oxidases using chloride as an oxygen surrogate.
Phaneeswara Rao Kommoju,Zhiwei Chen,Robert C. Bruckner,F. Scott Mathews,Marilyn Schuman Jorns +4 more
TL;DR: Chloride acts as an oxygen surrogate, is an effective probe of polar oxygen activation sites, and provides a valuable complementary tool to the xenon gas method that is used to map nonpolar oxygen-binding cavities.