Henry Sutanto

TL;DR: Preexisting Ca2+-handling abnormalities and activation of NLRP3-inflammasome/CaMKII signaling are evident in atrial cardiomyocytes from patients who subsequently develop POAF, revealing a potential cellular and molecular substrate for this important clinical problem.

TL;DR: The fundamental mechanisms of cardiomyocyte Ca2+ handling in health and disease are described, an overview of currently available computational models forCardiomyocytes Ca2-handling handling is provided, and important uncertainties and open questions about cardo- cardiac arrhythmias are discussed.

TL;DR: This study demonstrates that the analysis of large cross-ethnic population sequencing data can significantly improve disease variant interpretation, and suggests that a proportion of ARVC-causing variants may be inaccurately classified, implying reduced penetrance of some variants, and/or a polygenic aetiology of AR VC.

TL;DR: In this paper, a narrative review focuses on the emerging and future applications of computational modelling in atrial fibrillation (AF) management, and summarizes clinical challenges that may benefit from computational modelling, provide an overview of the different in silico approaches, and discuss the major limitations that hinder the routine clinical application of these approaches.

TL;DR: Low concentrations of ethanol can have anti-fibrillatory effects in atria, whereas high concentrations promote the inducibility and maintenance of reentrant atrial and ventricular arrhythmias, supporting a role for limiting alcohol intake as part of cardiac arrhythmia management.