H
Herbert M. Lachman
Researcher at Albert Einstein College of Medicine
Publications - 96
Citations - 7994
Herbert M. Lachman is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Gene & Catechol-O-methyl transferase. The author has an hindex of 41, co-authored 90 publications receiving 7669 citations. Previous affiliations of Herbert M. Lachman include University of Connecticut Health Center & Yeshiva University.
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Journal ArticleDOI
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
Herbert M. Lachman,Demitri F. Papolos,Takuya Saito,Yue Min Yu,Carol L. Szumlanski,Richard M. Weinshilboum +5 more
TL;DR: The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur.
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The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes.
TL;DR: It is hypothesized that the COMT Met allele (associated with low enzyme activity) results in increased levels of tonic DA and reciprocal reductions in phasic DA in subcortical regions and increased D1 transmission cortically.
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Expression of c-myc changes during differentiation of mouse erythroleukaemia cells
TL;DR: The level of c-myc messenger RNA shows a rapid biphasic change in MEL cells induced to differentiate by dimethyl sulphoxide or hypoxanthine during the first few hours of the differentiation programme and require active protein synthesis, suggesting that changes in c- myc expression may be important in the irreversible commitment of M EL cells to terminal erythroid differentiation.
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Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome
Herbert M. Lachman,Bernice E. Morrow,Robert J. Shprintzen,Sabine Veit,Sam S. Parsia,Gianni L. Faedda,Rosalie Goldberg,Raju Kucherlapati,Demitri F. Papolos +8 more
TL;DR: In a population of patients with VCFS, there is an apparent association between the low-activity allele, COMT158met, and the development of bipolar spectrum disorder, and in particular, a rapid-cycling form.
Journal ArticleDOI
Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior.
Tero Hallikainen,Takuya Saito,Herbert M. Lachman,Jan Volavka,Tiina Pohjalainen,Olli-Pekka Ryynänen,Jussi Kauhanen,Erkka Syvälahti,Jarmo Hietala,Jari Tiihonen +9 more
TL;DR: The results suggest that the 5-HTT ‘S’ promoter polymorphism is associated with an increased risk for early onset alcoholism associated with antisocial personality disorder and impulsive, habitually violent behavior.