H
Herbert M. Lachman
Researcher at Albert Einstein College of Medicine
Publications - 96
Citations - 7994
Herbert M. Lachman is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Gene & Catechol-O-methyl transferase. The author has an hindex of 41, co-authored 90 publications receiving 7669 citations. Previous affiliations of Herbert M. Lachman include University of Connecticut Health Center & Yeshiva University.
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Journal ArticleDOI
The Senegal DNA haplotype is associated with the amelioration of anemia in African-American sickle cell anemia patients.
Ronald L. Nagel,Soili Erlingsson,Mary E. Fabry,Helena Croizat,Sandra M. Susuka,Herbert M. Lachman,Millicent Sutton,Catherine Driscoll,Eric E. Bouhassira,Henny H. Billett +9 more
TL;DR: It is concluded that the Senegal beta-like globin gene cluster haplotype is associated with an amelioration of the hemolytic anemia that characterizes sickle cell disease.
Journal ArticleDOI
Contributions of transcriptional and post-transcriptional mechanisms to the regulation of c-myc expression in mouse erythroleukemia cells.
TL;DR: Results demonstrate that, except for the rapid decline in c-myc mRNA immediately following inducer treatment, all subsequent regulation of message levels occurs through post-transcriptional mechanisms.
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c-myc mRNA levels in the cell cycle change in mouse erythroleukemia cells following inducer treatment.
TL;DR: Treatment with inducers of differentiation leads to a change in the cell cycle regulation of c-myc mRNA, which may be involved in the altered proliferative capacity of the cells that occurs during terminal differentiation.
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Mutation analysis of SYNJ1 : a possible candidate gene for chromosome 21q22-linked bipolar disorder
TL;DR: Although it failed to unequivocally identify a specific SYNJ1 allele that could be responsible for putative chromosome 21q22-linked BPD, several interesting variants were found to be increased in bipolar subjects and should be further investigated.
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Long forms of the dopamine receptor (DRD4) gene VNTR are more prevalent in substance abusers: no interaction with functional alleles of the catechol-o-methyltransferase (COMT) gene.
David J. Vandenbergh,Lawrence A. Rodriguez,Elisabeth Hivert,Jocelyn H. Schiller,Greg Villareal,Elisabeth W. Pugh,Herbert M. Lachman,George R. Uhl +7 more
TL;DR: It is shown that the long form of the DRD4 gene is more frequent in individuals with high quantity/frequency of drug use compared to controls, and there is no difference in DRD3 allele frequencies in these samples.