H
Herbert M. Lachman
Researcher at Albert Einstein College of Medicine
Publications - 96
Citations - 7994
Herbert M. Lachman is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Gene & Catechol-O-methyl transferase. The author has an hindex of 41, co-authored 90 publications receiving 7669 citations. Previous affiliations of Herbert M. Lachman include University of Connecticut Health Center & Yeshiva University.
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An association between a polymorphism of the tryptophan hydroxylase gene and aggression in schizophrenia and schizoaffective disorder.
TL;DR: The results tend to support previous reports by New el al. (1996; 1998) of an association between the TPH L allele and impulsive aggression in males with personality disorder, but larger studies are needed.
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Effects of the antiglucocorticoid RU 38486 on the induction of learned helpless behavior in Sprague-Dawley rats
TL;DR: The findings suggest that glucocorticoids exert a long-term influence on stress-induced behavior, presumably by affecting glucoc Corticoid responsive genes in the dentate gyrus.
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Analysis of polymorphisms in AT-rich domains of neuregulin 1 gene in schizophrenia
TL;DR: The findings support a role for NRG1 in SZ in African Americans and suggest that polymorphic differences in regions of the gene that recognize AT‐binding proteins may be a factor in disease pathogenesis.
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Analysis of an association between the COMT polymorphism and clinical symptomatology in schizophrenia.
TL;DR: It may be suggested that a modifying gene may be required in order for the COMT polymorphism to manifest at the clinical level in schizophrenia with one set of susceptibility genes being more sensitive to COMT enzyme variability than others.
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Sickle gene. Its origin and diffusion from West Africa.
J. G. Mears,Herbert M. Lachman,R. Cabannes,K. P. E. Amegnizin,Dominique Labie,Ronald L. Nagel +5 more
TL;DR: Analysis of linkage to a polymorphic Hpa 1 site appearing 3' to the beta-globin gene locus in selected populations from Wes Africa shows consistent with the selection and expansion of two different chromosomes bearing beta S-genes in at least two physically close, but ethnically separate regions of West Africa, with subsequent diffusion to North, Equatorial, and East Africa.