H
Herbert M. Lachman
Researcher at Albert Einstein College of Medicine
Publications - 96
Citations - 7994
Herbert M. Lachman is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Gene & Catechol-O-methyl transferase. The author has an hindex of 41, co-authored 90 publications receiving 7669 citations. Previous affiliations of Herbert M. Lachman include University of Connecticut Health Center & Yeshiva University.
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Mitochondrial deficits in human iPSC-derived neurons from patients with 22q11.2 deletion syndrome and schizophrenia.
Jianping Li,Sean K. Ryan,Erik M. DeBoer,Kieona Cook,Shane Fitzgerald,Herbert M. Lachman,Douglas C. Wallace,Ethan M. Goldberg,Stewart A. Anderson +8 more
TL;DR: The results suggest that in the 22q11DS MRPL40 heterozygosity leads to reduced mitochondria ATP production secondary to altered mitochondrial protein levels, which could have profound effects on neuronal function in vivo.
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Abnormal signal transduction: A hypothetical model for bipolar affective disorder
TL;DR: This paper presents a model in which abnormal regulation of signal transduction could lead to the episodic accumulation of biologically active transducers or second messengers, which may result in prolonged effector stimulation which may underlie mania, followed by excessive receptor desensitization, which could result in depression.
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Differential effect of lithium on fos protooncogene expression mediated by receptor and postreceptor activators of protein kinase C and cyclic adenosine monophosphate: model for its antimanic action.
M. M. Divish,Giulia Sheftel,A. Boyle,Vasundhara D. Kalasapudi,Demitri F. Papolos,Herbert M. Lachman +5 more
TL;DR: Lithium, at therapeutic doses, has an augmenting effect on phosphatidylinositol (PI)‐mediated fos expression induced by activating a muscarinic cholinergic pathway, whereas it has no effect, at tenfold the therapeutic dose, on fosexpression induced by receptor or postreceptor activators of cyclic adenosine monophosphate (cAMP).
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Heat shock alters the expression of schizophrenia and autism candidate genes in an induced pluripotent stem cell model of the human telencephalon.
TL;DR: The findings suggest that some candidate genes that are assumed to have a relatively limited impact on SZ and ASD pathogenesis based on a small number of positive genetic findings may in fact have a much more substantial role in these disorders - as targets of common environmental stressors.
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Patch-clamp recordings and calcium imaging followed by single-cell PCR reveal the developmental profile of 13 genes in iPSC-derived human neurons.
Glenn S. Belinsky,Matthew T. Rich,Carissa L. Sirois,Shaina M. Short,Erika Pedrosa,Herbert M. Lachman,Srdjan D. Antic +6 more
TL;DR: The results demonstrate that in the earliest stages of neuron development, it is useful to combine genetic analysis with physiological characterizations, on a cell-to-cell basis.