H
Herbert R. Wenzel
Researcher at Bielefeld University
Publications - 45
Citations - 791
Herbert R. Wenzel is an academic researcher from Bielefeld University. The author has contributed to research in topics: Aprotinin & Trypsin. The author has an hindex of 15, co-authored 45 publications receiving 785 citations. Previous affiliations of Herbert R. Wenzel include Temple University & Bayer.
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Journal ArticleDOI
Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.
Jörg Schröder,Andreas Henke,Herbert R. Wenzel,Hans Brandstetter,Hans G. Stammler,Anja Stammler,Wolf D. Pfeiffer,Harald Tschesche +7 more
TL;DR: A unique combination of the above-described modifications produced the selective inhibitor (2R)-N-[5-(4-bromophenyl)-6H-1,3,4-thiadiazin-2-yl]-2-[(phenylsulfonyl)amino]propanamide with high affinity for MMP-9 (K(i) = 40 nM).
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The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor.
TL;DR: The X-ray crystal structure of the ternary complex of trypsinogen-[Arg15]PTI with the dipeptide Val-Val with a final R-value of 0.17 has been determined and part of the positive free energy change observed upon replacement of Ile-Val may allow for the maintenance of this cavity.
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Stability studies on derivatives of the bovine pancreatic trypsin-inhibitor
TL;DR: This finding demonstrates that the presence of two negative charges reduces the higher stability of BPTI-RCAM slightly; however, the overall effect of the two charges is still a stabilization.
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Preparation of chemically mutated aprotinin homologues by semisynthesis: P1 substitutions change inhibitory specificity
TL;DR: BPTI was shown to be an excellent inhibitor for human polymorphonuclear leukocyte elastase having a complex dissociation constant of 0.11 nM and showed no detectable affinity to bovine pancreatic trypsin.
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Selective kallikrein inhibitors alter human neutrophil elastase release during extracorporeal circulation
Y T Wachtfogel,C.E. Hack,J.H Nuijens,C. Kettner,T.M. Reilly,R.M. Knabb,Rainer Bischoff,Harald Tschesche,Herbert R. Wenzel,Umberto Kucich +9 more
TL;DR: The results suggest that low-molecular-weight selective inhibitors of kallikrein may be effective agents in the attenuation of the contact-mediated inflammatory response in cardiopulmonary bypass.