Heung Sik Hahm

TL;DR: A small-molecule combination, BIX-01294 and BayK8644, is identified that enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts, which do not endogenously express the factors essential for reprograming.

TL;DR: Two approaches toward identifying conditions that can replace viral transduction of oncogenic transcription factors (TFs) and enhance reprogramming efficiency are explored, with one finding that neural progenitor cells can be reprogrammed with fewer genetic manipulations than previously reported somatic cells.

TL;DR: A chemical approach is described that dramatically improves the efficiency of iPSC generation from human fibroblasts, within seven days of treatment, which will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.

TL;DR: It is shown that the primary cause of hESC death following enzymatic dissociation comes from an irreparable disruption of E-cadherin signaling, which then leads to a fatal perturbation of integrin signaling, and the resulting survival of ESCs were controlled by specific growth factor signaling.

TL;DR: It is demonstrated that ion mobility–mass spectrometry—a method that separates molecules according to their mass, charge, size, and shape—can unambiguously identify carbohydrate linkage-isomers and stereoisomers, and could have an impact on the field of carbohydrate synthesis similar to that of the advent of high-performance liquid chromatography on the fields of peptide assembly in the late 1970s.