H
Hideki Okazawa
Researcher at University of California, San Diego
Publications - 2
Citations - 764
Hideki Okazawa is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 2, co-authored 2 publications receiving 649 citations.
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Journal ArticleDOI
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
Ian Lian,Joungmok Kim,Hideki Okazawa,Jiagang Zhao,Bin Zhao,Jindan Yu,Arul M. Chinnaiyan,Mason A. Israel,Lawrence S.B. Goldstein,Ramzey Abujarour,Sheng Ding,Kun-Liang Guan +11 more
TL;DR: It is reported that YAP is inactivated during embryonic stem (ES) cell differentiation, as indicated by decreased protein levels and increased phosphorylation, which establishes a critical role of YAP in maintaining stem cell pluripotency.
Journal ArticleDOI
mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.
Huibin Tang,Huibin Tang,Ken Inoki,Susan V. Brooks,Hideki Okazawa,Myung Chang Lee,Myung Chang Lee,Junying Wang,Michael Kim,Michael Kim,Catherine L. Kennedy,Catherine L. Kennedy,Peter C. D. Macpherson,Xuhuai Ji,Sabrina Van Roekel,Danielle A. Fraga,Danielle A. Fraga,Kun Wang,Kun Wang,Jinguo Zhu,Jinguo Zhu,Yoyo Wang,Yoyo Wang,Zelton D Sharp,Richard A. Miller,Thomas A. Rando,Thomas A. Rando,Daniel Goldman,Kun-Liang Guan,Joseph B. Shrager,Joseph B. Shrager +30 more
TL;DR: It is shown here that mTORC1 signaling is activated in a subset of skeletal muscle fibers in aging mouse and human, colocalized with fiber damage.