J
Jindan Yu
Researcher at Northwestern University
Publications - 94
Citations - 19111
Jindan Yu is an academic researcher from Northwestern University. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 48, co-authored 94 publications receiving 16725 citations. Previous affiliations of Jindan Yu include University of Michigan.
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Journal ArticleDOI
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
Bin Zhao,Xiaomu Wei,Weiquan Li,Ryan S. Udan,Ryan S. Udan,Qian Yang,Joungmok Kim,Joungmok Kim,Joe Xie,Tsuneo Ikenoue,Jindan Yu,Li Li,Li Li,Pan Zheng,Keqiang Ye,Arul M. Chinnaiyan,Georg Halder,Georg Halder,Zhi Chun Lai,Kun-Liang Guan,Kun-Liang Guan +20 more
TL;DR: It is demonstrated that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway, and YAP overexpression regulates gene expression in a manner opposite to cell density, and is able to overcome cell contact inhibition.
Journal ArticleDOI
TEAD mediates YAP-dependent gene induction and growth control
Bin Zhao,Xin Ye,Jindan Yu,Li Li,Li Li,Weiquan Li,Siming Li,Jianjun Yu,Jiandie D. Lin,Cun-Yu Wang,Arul M. Chinnaiyan,Zhi Chun Lai,Kun-Liang Guan +12 more
TL;DR: TEAD is revealed as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP, and is required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition.
Journal ArticleDOI
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
Arun Sreekumar,Laila M. Poisson,Thekkelnaycke M. Rajendiran,Amjad Khan,Qi Cao,Jindan Yu,Bharathi Laxman,Rohit Mehra,Robert J. Lonigro,Yong Li,Mukesh K. Nyati,Aarif Ahsan,Shanker Kalyana-Sundaram,Bo Han,Xuhong Cao,Jaeman Byun,Gilbert S. Omenn,Debashis Ghosh,Subramaniam Pennathur,Danny C. Alexander,Alvin Berger,Jeffrey R. Shuster,John T. Wei,Sooryanarayana Varambally,Christopher A. Beecher,Arul M. Chinnaiyan +25 more
TL;DR: Sarcosine, an N-methyl derivative of the amino acid glycine, was identified as a differential metabolite that was highly increased during prostate cancer progression to metastasis and can be detected non-invasively in urine.
Journal ArticleDOI
Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer
Sooryanarayana Varambally,Qi Cao,Ram Shankar Mani,Sunita Shankar,Xiaosong Wang,Bushra Ateeq,Bharathi Laxman,Xuhong Cao,Xiaojun Jing,Kalpana Ramnarayanan,J. Chad Brenner,Jindan Yu,Jung H. Kim,Bo Han,Patrick Tan,Chandan Kumar-Sinha,Robert J. Lonigro,Nallasivam Palanisamy,Nallasivam Palanisamy,Christopher G. Maher,Arul M. Chinnaiyan +20 more
TL;DR: The expression and function of EZH2 in cancer cell lines are inhibited by microRNA-101 and it is proposed that the genomic loss of miR-101 in cancer leads to overexpression of EzH2 and concomitant dysregulation of epigenetic pathways, resulting in cancer progression.
Journal ArticleDOI
Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
Qianben Wang,Wei Li,Yong Zhang,Xin Yuan,Kexin Xu,Jindan Yu,Zhong Chen,Rameen Beroukhim,Rameen Beroukhim,Hongyun Wang,Mathieu Lupien,Tao Wu,Meredith M. Regan,Clifford A. Meyer,Jason S. Carroll,Arjun K. Manrai,Olli A. Jänne,Steven P. Balk,Rohit Mehra,Bo Han,Arul M. Chinnaiyan,Mark A. Rubin,Lawrence D. True,Michelangelo Fiorentino,Christopher Fiore,Massimo Loda,Philip W. Kantoff,X. Shirley Liu,Myles Brown +28 more
TL;DR: The role of AR in androgen-independent cancer cells is not to direct the androgen -dependent gene expression program without androgen, but rather to execute a distinct program resulting in androgens-independent growth.