H
Hien Chau
Researcher at University Health Network
Publications - 14
Citations - 553
Hien Chau is an academic researcher from University Health Network. The author has contributed to research in topics: Neurodegeneration & Proteostasis. The author has an hindex of 8, co-authored 13 publications receiving 441 citations. Previous affiliations of Hien Chau include Toronto Western Hospital & University of Toronto.
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Journal ArticleDOI
Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).
Lorraine V. Kalia,Lorraine V. Kalia,Suneil K. Kalia,Suneil K. Kalia,Hien Chau,Andres M. Lozano,Bradley T. Hyman,Pamela J. McLean +7 more
TL;DR: It is demonstrated that α-syn is ubiquitinylated by CHIP both in vitro and in cells and a novel function for BAG5 as a modulator of CHIP E3 ubiquitin ligase activity is suggested with implications for CHIP-mediated regulation of α- syn oligomerization.
Journal ArticleDOI
Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors
Nien Jung Chen,Iok In Christine Chio,Iok In Christine Chio,Wen-Jye Lin,Wen-Jye Lin,Gordon S. Duncan,Gordon S. Duncan,Hien Chau,Hien Chau,Hien Chau,David F. Katz,David F. Katz,David F. Katz,Huey-Lan Huang,Huey-Lan Huang,Huey-Lan Huang,Kelly A. Pike,Kelly A. Pike,Kelly A. Pike,Zhenyue Hao,Zhenyue Hao,Yu-Wen Su,Yu-Wen Su,Kazuo Yamamoto,Kazuo Yamamoto,Renée F. de Pooter,Juan Carlos Zúñiga-Pflücker,Andrew Wakeham,Andrew Wakeham,Wen Chen Yeh,Wen Chen Yeh,Tak W. Mak,Tak W. Mak +32 more
TL;DR: Tumor necrosis factor receptor 1-associated death domain protein (TRADD) is the core adaptor recruited to TNF receptor 1 (TNFR1) upon TNFα stimulation and has a novel role in TLR3 and TLR4 signaling.
Journal ArticleDOI
Cellular FLICE-inhibitory protein is required for T cell survival and cycling
Hien Chau,Veronica Wong,Veronica Wong,Nien Jung Chen,Nien Jung Chen,Huey-Lan Huang,Huey-Lan Huang,Wen-Jye Lin,Wen-Jye Lin,Christine Mirtsos,Christine Mirtsos,Alisha R. Elford,Alisha R. Elford,Madeleine Bonnard,Andrew Wakeham,Andrew Wakeham,Annick You-Ten,Annick You-Ten,Bénédicte Lemmers,Leonardo Salmena,Marc Pellegrini,Marc Pellegrini,Razq Hakem,Tak W. Mak,Tak W. Mak,Pamela S. Ohashi,Pamela S. Ohashi,Wen Chen Yeh,Wen Chen Yeh +28 more
TL;DR: It is demonstrated that an essential role for cFLIP in T cell function is demonstrated, as it is required for T cell survival, as well as T cell cycling in response to TCR stimulation.
Journal ArticleDOI
Rapid Modulation of Protein Expression in the Rat Hippocampus Following Deep Brain Stimulation of the Fornix.
Elise Gondard,Hien Chau,Amandeep Mann,Travis S. Tierney,Clement Hamani,Clement Hamani,Suneil K. Kalia,Suneil K. Kalia,Andres M. Lozano,Andres M. Lozano +9 more
TL;DR: Forniceal DBS triggers hippocampal activity and rapidly modulate the expression of neurotrophic factors and markers of synaptic plasticity known to play key roles in memory processing.
Journal ArticleDOI
Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein
Chris McKinnon,Mitchell L. De Snoo,Elise Gondard,Clemens Neudorfer,Hien Chau,Sophie G. Ngana,Darren M O'Hara,Jonathan M. Brotchie,James B. Koprich,Andres M. Lozano,Lorraine V. Kalia,Suneil K. Kalia +11 more
TL;DR: It is found that α-synuclein over-expression leads to early-onset catalytic impairment of the 26S proteasome with associated UPS dysfunction, preceding the onset of behavioural deficits and dopaminergic neurodegeneration in rat SNpc.