G
Gordon S. Duncan
Researcher at University Health Network
Publications - 56
Citations - 15750
Gordon S. Duncan is an academic researcher from University Health Network. The author has contributed to research in topics: Immune system & Apoptosis. The author has an hindex of 44, co-authored 53 publications receiving 14912 citations. Previous affiliations of Gordon S. Duncan include University of Toronto & Discovery Institute.
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Journal ArticleDOI
Differential requirement for caspase 9 in apoptotic pathways in vivo
Razqallah Hakem,Razqallah Hakem,Anne Hakem,Anne Hakem,Gordon S. Duncan,Gordon S. Duncan,Jeffrey T. Henderson,Minna Woo,Minna Woo,Maria S. Soengas,Andrew E. H. Elia,Andrew E. H. Elia,José Luis de la Pompa,José Luis de la Pompa,David Kägi,David Kägi,Wilson Khoo,Wilson Khoo,Julia Potter,Julia Potter,Ritsuko Yoshida,Ritsuko Yoshida,Stephen Kaufman,Scott W. Lowe,Josef M. Penninger,Josef M. Penninger,Tak W. Mak,Tak W. Mak +27 more
TL;DR: Comparison of the requirement for Casp9 and Casp3 in different apoptotic settings indicates the existence of at least four different apoptosis pathways in mammalian cells.
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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
Mark A. Lomaga,Wen Chen Yeh,Ildiko Sarosi,Gordon S. Duncan,Caren Furlonger,Alexandra Ho,Sean Morony,Casey Capparelli,Gwyneth Van,Stephen Kaufman,Annette Van Der Heiden,Annick Itie,Andrew Wakeham,Wilson Khoo,Takehiko Sasaki,Zhaodan Cao,Josef M. Penninger,Christopher J. Paige,David L. Lacey,Colin R. Dunstan,William J. Boyle,David V. Goeddel,Tak W. Mak +22 more
TL;DR: It is reported that mice deficient in TNF receptor-associated factor 6 (TRAF6) are osteopetrotic with defects in bone remodeling and tooth eruption due to impaired osteoclast function, and it is demonstrated that TRAF6 is crucial not only in IL-1 and CD40 signaling but also, surprisingly, in LPS signaling.
Journal ArticleDOI
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
Akinori Takaoka,Hideyuki Yanai,Seiji Kondo,Gordon S. Duncan,Hideo Negishi,Tatsuaki Mizutani,Shin Ichi Kano,Kenya Honda,Yusuke Ohba,Tak W. Mak,Tadatsugu Taniguchi +10 more
TL;DR: The transcription factor IRF-5 is identified as a new, principal downstream regulator of the TLR–MyD88 signalling pathway and a potential target of therapeutic intervention to control harmful immune responses.
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Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
Minna Woo,Razqallah Hakem,Maria S. Soengas,Gordon S. Duncan,Arda Shahinian,David Kägi,Anne Hakem,Mila E. McCurrach,Wilson Khoo,Stephen Kaufman,Giorgio Senaldi,Tamara Howard,Scott W. Lowe,Tak W. Mak +13 more
TL;DR: Examination of the role of CPP32 in apoptosis using mice, embryonic stem cells, and mouse embryonic fibroblasts deficient for the caspase indicates that CPP 32 is an essential component in apoptotic events that is remarkably system- and stimulus-dependent.
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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
Nobutaka Suzuki,Shinobu Suzuki,Gordon S. Duncan,Douglas G. Millar,Teiji Wada,Christine Mirtsos,Hidetoshi Takada,Andrew Wakeham,Annick Itie,Shyun Li,Josef M. Penninger,Holger Wesche,Pamela S. Ohashi,Tak W. Mak,Wen Chen Yeh +14 more
TL;DR: It is shown by gene-targeting that IRAK-4, an IRAK molecule closely related to the Drosophila Pelle protein, is indispensable for the responses of animals and cultured cells to IL-1 and ligands that stimulate various TLRs.