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Bénédicte Lemmers
Researcher at Centre national de la recherche scientifique
Publications - 33
Citations - 2978
Bénédicte Lemmers is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Cyclin A2 & Cyclin D. The author has an hindex of 21, co-authored 31 publications receiving 2728 citations. Previous affiliations of Bénédicte Lemmers include University of Montpellier & University of Toronto.
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Journal ArticleDOI
Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation
Roger P. Leng,Yunping Lin,Weili Ma,Hong Wu,Bénédicte Lemmers,Bénédicte Lemmers,Stephen Chung,John M. Parant,Guillermina Lozano,Razqallah Hakem,Razqallah Hakem,Samuel Benchimol +11 more
TL;DR: Pirh2, a gene regulated by p53 that encodes a RING-H2 domain-containing protein with intrinsic ubiquitin-protein ligase activity, is described and it is proposed that Pirh2 is involved in the negative regulation of p53 function through physical interaction and ubiquit in-mediated proteolysis.
Journal ArticleDOI
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity
Leonardo Salmena,Bénédicte Lemmers,Anne Hakem,Elzbieta Matysiak-Zablocki,Kiichi Murakami,P.Y. Billie Au,Donna M Berry,Laura Tamblyn,Amro Shehabeldin,Eva Migon,Andrew Wakeham,Denis Bouchard,Wen Chen Yeh,J McGlade,Pamela S. Ohashi,Razqallah Hakem +15 more
TL;DR: An essential, cell-stage-specific role for caspase 8 in T- cell homeostasis and T-cell-mediated immunity is identified, consistent with the recent identification of caspases 8 mutations in human immunodeficiency.
Journal ArticleDOI
Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity
John Peter McPherson,Laura Tamblyn,Andrew E. H. Elia,Eva Migon,Amro Shehabeldin,Elzbieta Matysiak-Zablocki,Bénédicte Lemmers,Leonardo Salmena,Anne Hakem,Jason E. Fish,Farah Kassam,Jeremy A. Squire,Benoit G. Bruneau,M. Prakash Hande,Razqallah Hakem +14 more
TL;DR: Findings indicate an essential role of Lats2 in the integrity of processes that govern centrosome duplication, maintenance of mitotic fidelity and genomic stability.
Journal ArticleDOI
Involvement of mammalian Mus81 in genome integrity and tumor suppression.
John Peter McPherson,John Peter McPherson,Bénédicte Lemmers,Bénédicte Lemmers,Richard Chahwan,Richard Chahwan,Ashwin Pamidi,Ashwin Pamidi,Eva Migon,Eva Migon,Elzbieta Matysiak-Zablocki,Elzbieta Matysiak-Zablocki,Mary Ellen Moynahan,Jeroen Essers,Katsuhiro Hanada,Anuradha Poonepalli,Otto Sanchez-Sweatman,Rama Khokha,Roland Kanaar,Maria Jasin,M. Prakash Hande,Razqallah Hakem,Razqallah Hakem +22 more
TL;DR: A critical role is demonstrated for the proper biallelic expression of the mammalian Mus81 in the maintenance of genomic integrity and tumor suppression and a similar susceptibility to spontaneous chromosomal damage and a profound and equivalent predisposition to lymphomas and other cancers.
Journal ArticleDOI
Essential role for caspase-8 in toll-like receptors and NFκB signaling
Bénédicte Lemmers,Bénédicte Lemmers,Bénédicte Lemmers,Leonardo Salmena,Leonardo Salmena,Leonardo Salmena,Nicolas Bidère,Helen C. Su,Elzbieta Matysiak-Zablocki,Elzbieta Matysiak-Zablocki,Elzbieta Matysiak-Zablocki,Kiichi Murakami,Kiichi Murakami,Kiichi Murakami,Pamela S. Ohashi,Pamela S. Ohashi,Pamela S. Ohashi,Andrea Jurisicova,Michael J. Lenardo,Razqallah Hakem,Razqallah Hakem,Razqallah Hakem,Anne Hakem,Anne Hakem,Anne Hakem +24 more
TL;DR: It is shown that caspase-8 is dispensable for B-cell development, but its loss in B cells results in attenuated antibody production upon in vivo viral infection, and its requirement for TLR signaling and in the regulation of NFκB function is demonstrated.