H
Hiroaki Mitsuya
Researcher at National Institutes of Health
Publications - 26
Citations - 451
Hiroaki Mitsuya is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Nucleoside & Dideoxynucleosides. The author has an hindex of 8, co-authored 26 publications receiving 361 citations. Previous affiliations of Hiroaki Mitsuya include Fukushima Medical University & Kumamoto University.
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Journal ArticleDOI
Potential anti-AIDS drugs. 2',3'-Dideoxycytidine analogues.
TL;DR: An attempt was made to utilize ddCMP, ddTMP, and ddAMP as preformed nucleotides in order to circumvent the generally low level of phosphorylation achieved with dideoxynucleosides which function as relatively poor substrates for the cellular kinases.
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Syntheses of 4‘-C-Ethynyl-β-d-arabino- and 4‘-C-Ethynyl-2‘-deoxy-β-d-ribo-pentofuranosylpyrimidines and -purines and Evaluation of Their Anti-HIV Activity
Hiroshi Ohrui,Satoru Kohgo,Kenji Kitano,Sakata Shinji,Eiichi Kodama,Kazuhisa Yoshimura,Masao Matsuoka,Shiro Shigeta,Hiroaki Mitsuya +8 more
TL;DR: In this article, 4'-C-ethynyl-2'-deoxy-ribo derivatives were synthesized by radical reduction of 2'-bromo or 2'- phenoxythiocarbonyloxy nucleosides.
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Correlates of neutralizing/SARS-CoV-2-S1-binding antibody response with adverse effects and immune kinetics in BNT162b2-vaccinated individuals.
Kenji Maeda,Masayuki Amano,Yukari Uemura,Kiyoto Tsuchiya,Tomoko Matsushima,Kenta Noda,Yosuke Shimizu,Asuka Fujiwara,Yuki Takamatsu,Yasuko Ichikawa,Hidehiro Nishimura,Mari Kinoshita,Shota Matsumoto,Hiroyuki Gatanaga,Kazuhisa Yoshimura,Shinichi Oka,Ayako Mikami,Wataru Sugiura,Toshiyuki Sato,Tomokazu Yoshida,Shinya Shimada,Hiroaki Mitsuya,Hiroaki Mitsuya +22 more
TL;DR: In this article, the authors examined the effect of BNT162b2-elicited SARS-CoV-2 neutralizing activity (50% neutralization titer: NT50; assessed using infectious virions) with various determinants and the potency of sera against variants of concerns.
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2′-deoxy-4′-C-ethynyl-2-fluoroadenosine: A nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma
Hiroshi Ohrui,Satoru Kohgo,Hiroyuki Hayakawa,Eiichi Kodama,Masao Matsuoka,Tomohiro Nakata,Hiroaki Mitsuya +6 more
TL;DR: The study based on the hypotheses proved the validity of the hypotheses and resulted in the development of 2′-deoxy-4′-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, with highly potent activity against all HIV-1, very favorable toxic profiles, and stability in plasma.
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Chemistry and anti-HIV properties of 2'-fluoro-2',3'-dideoxyarabinofuranosylpyrimidines.
Maqbool A. Siddiqui,John S. Driscoll,Victor E. Marquez,Jay S. Roth,Takuma Shirasaka,Hiroaki Mitsuya,Joseph J. Barchi,James A. Kelley +7 more
TL;DR: 2'-Fluoro substitution confers increased chemical and enzymatic stability on dideoxynucleosides and gives complete protection against the cytopathic effects of HIV in both host cell lines.