Hiroaki Tomita

TL;DR: The astroglial distribution of the two glutamate transporters and l-glutamate-ammonia ligase strongly links glia to the pathophysiology of depression and challenges the conventional notion that depression is solely a neuronal disorder.

TL;DR: The results indicate that haploinsufficiency of NSD1 is the major cause of Sotos syndrome.

TL;DR: Findings that imply dysregulation of several fibroblast growth factor (FGF) system transcripts in frontal cortical regions of brains from human subjects with major depressive disorder (MDD) are described and all of the other growth factors and growth factor receptors detected in these postmortem samples are made available.

TL;DR: It is reported that agonal factors significantly affect RNA integrity and have a major impact on gene expression profiles in microarrays, and the Average Correlation Index is proposed as a method for evaluating RNA integrity on the basis of similarity of microarray profiles.

TL;DR: These findings shed light on critical molecular mechanisms that are engaged during different forms of terminal stress, and may suggest clinical targets of protection or restoration for psychiatric or neurological disorders.