S
Simon J. Evans
Researcher at University of Michigan
Publications - 72
Citations - 5205
Simon J. Evans is an academic researcher from University of Michigan. The author has contributed to research in topics: Bipolar disorder & Mood disorders. The author has an hindex of 33, co-authored 72 publications receiving 4703 citations. Previous affiliations of Simon J. Evans include Institute for Systems Biology & University of Leicester.
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Journal ArticleDOI
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
Prabhakara V. Choudary,Margherita Molnar,Simon J. Evans,Hiroaki Tomita,Jun Li,Marquis P. Vawter,Richard M. Myers,William E. Bunney,Huda Akil,Stanley J. Watson,Edward G. Jones +10 more
TL;DR: The astroglial distribution of the two glutamate transporters and l-glutamate-ammonia ligase strongly links glia to the pathophysiology of depression and challenges the conventional notion that depression is solely a neuronal disorder.
Journal ArticleDOI
Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
Jun Li,Blynn G. Bunney,Fan Meng,Megan Hastings Hagenauer,David M. Walsh,Marquis P. Vawter,Simon J. Evans,Prabhakara V. Choudary,Preston M. Cartagena,Jack D. Barchas,Alan F. Schatzberg,Edward G. Jones,Richard M. Myers,Stanley J. Watson,Huda Akil,William E. Bunney +15 more
TL;DR: A transcriptome-wide analysis of the human brain demonstrates a rhythmic rise and fall of gene expression in regions outside of the suprachiasmatic nucleus in control subjects, which suggests potentially important molecular targets for treatment of mood disorders.
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Dysregulation of the fibroblast growth factor system in major depression
Simon J. Evans,Prabhakara V. Choudary,Charles R. Neal,Jun Li,Marquis P. Vawter,Hiroaki Tomita,Juan F. Lopez,Robert C. Thompson,Fan Meng,John D.H. Stead,D. M. Walsh,Richard M. Myers,William E. Bunney,S.J. Watson,Edward G. Jones,Huda Akil +15 more
TL;DR: Findings that imply dysregulation of several fibroblast growth factor (FGF) system transcripts in frontal cortical regions of brains from human subjects with major depressive disorder (MDD) are described and all of the other growth factors and growth factor receptors detected in these postmortem samples are made available.
Journal ArticleDOI
Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain.
Hiroaki Tomita,Marquis P. Vawter,David M. Walsh,Simon J. Evans,Prabhakara V. Choudary,Jun Li,Kevin Overman,Mary Atz,Richard M. Myers,Edward G. Jones,Stanley J. Watson,Huda Akil,William E. Bunney +12 more
TL;DR: It is reported that agonal factors significantly affect RNA integrity and have a major impact on gene expression profiles in microarrays, and the Average Correlation Index is proposed as a method for evaluating RNA integrity on the basis of similarity of microarray profiles.
Journal ArticleDOI
Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions
Jun Li,Marquis P. Vawter,David M. Walsh,Hiroaki Tomita,Simon J. Evans,Prabhakara V. Choudary,Juan F. Lopez,Abigail Avelar,Vida Shokoohi,Tisha Chung,Omar A. Mesarwi,Edward G. Jones,Stanley J. Watson,Huda Akil,William E. Bunney,Richard M. Myers +15 more
TL;DR: These findings shed light on critical molecular mechanisms that are engaged during different forms of terminal stress, and may suggest clinical targets of protection or restoration for psychiatric or neurological disorders.