Prabhakara V. Choudary

TL;DR: The astroglial distribution of the two glutamate transporters and l-glutamate-ammonia ligase strongly links glia to the pathophysiology of depression and challenges the conventional notion that depression is solely a neuronal disorder.

TL;DR: A transcriptome-wide analysis of the human brain demonstrates a rhythmic rise and fall of gene expression in regions outside of the suprachiasmatic nucleus in control subjects, which suggests potentially important molecular targets for treatment of mood disorders.

TL;DR: It is demonstrated that a portion of this highly conserved segment of repetitive mamalian DNA sequence is similar to a sequence found within a low molecular weight RNA that hydrogen-bonds to poly(A)-terminated RNA molecules of Chinese hamsters and a sequence that forms half of a perfect inverted repeat near the origin of DNA replication in papovaviruses.

TL;DR: Findings that imply dysregulation of several fibroblast growth factor (FGF) system transcripts in frontal cortical regions of brains from human subjects with major depressive disorder (MDD) are described and all of the other growth factors and growth factor receptors detected in these postmortem samples are made available.

TL;DR: It is reported that agonal factors significantly affect RNA integrity and have a major impact on gene expression profiles in microarrays, and the Average Correlation Index is proposed as a method for evaluating RNA integrity on the basis of similarity of microarray profiles.