H
Hiroki Ishikawa
Researcher at Okinawa Institute of Science and Technology
Publications - 17
Citations - 6157
Hiroki Ishikawa is an academic researcher from Okinawa Institute of Science and Technology. The author has contributed to research in topics: Innate immune system & Endoplasmic reticulum. The author has an hindex of 10, co-authored 13 publications receiving 4979 citations. Previous affiliations of Hiroki Ishikawa include University of Miami.
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Journal ArticleDOI
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: The identification of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes is reported, implying a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.
Journal ArticleDOI
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
TL;DR: It is shown that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species produced by various DNA pathogens after infection.
Journal ArticleDOI
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling (Nature (2008) 455, (674-678))
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: This corrects the article to show that the H2O2/H2O/O2 mixture is dominated by the H3O/ O2 mixture, rather than the O2/O3 mixture, which is more commonly associated with H2Os.
Journal ArticleDOI
Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity
Huihui Chen,Hui Sun,Fuping You,Wenxiang Sun,Xiang Zhou,Lu Chen,Jing Yang,Yutao Wang,Hong Tang,Yukun Guan,Weiwei Xia,Jun Gu,Hiroki Ishikawa,Delia Gutman,Glen N. Barber,Zhihai Qin,Zhengfan Jiang,Zhengfan Jiang +17 more
TL;DR: STAT6 mediates immune signaling in response to both cytokines at the plasma membrane, and virus infection at the endoplasmic reticulum, and Stat6(-/-) mice are susceptible to virus infection.
Journal ArticleDOI
The STING pathway and regulation of innate immune signaling in response to DNA pathogens
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: Recent discoveries relating to the detection of foreign DNA, including the importance of the STING and inflammasome pathways and the triggering of innate signaling processes are reviewed.