Delia Gutman

TL;DR: It is found that MM cells have a lower threshold for PI-induced UPR induction and ER stress-induced apoptosis because they constitutively express ER stress survival factors to function as secretory cells.

TL;DR: Stimulator of IFN Genes (STING) is responsible for inflammation-related embryonic death in DNase II defective mice initiated by self DNA, providing significant molecular insight into the causes of DNA-mediated inflammatory disorders and affords a target that could plausible be therapeutically controlled to help prevent such diseases.

TL;DR: It is shown that DENV NS2B3 is not able to degrade the mouse version of STING, a phenomenon that severely restricts the replication of DENV in mouse cells, suggesting that STING plays a key role in the inhibition ofDENV infection and spread in mice.

TL;DR: STAT6 mediates immune signaling in response to both cytokines at the plasma membrane, and virus infection at the endoplasmic reticulum, and Stat6(-/-) mice are susceptible to virus infection.

TL;DR: It is demonstrated that STING (stimulator of interferon genes), an endoplasmic reticulum translocon-associated transmembrane protein, acts to detect cytoplasmic DNA species and facilitates adoptive responses that are required for protection of the host.