https://imechanica.org/files/Qiu_environmental_sensitive_hydrogel.pdf

Environment-sensitive hydrogels for drug delivery

Thermo- and pH-responsive polymers in drug delivery.

Stimuli-reponsive polymers and their bioconjugates

Biomolecule-sensitive hydrogels.

Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs. From early beginnings using off-the-shelf materials, the field has grown tremendously, driven in part by the innovations of chemical engineers. Modern advances in drug delivery are now predicated upon the rational design of polymers tailored for specific cargo and engineered to exert distinct biological functions. In this review, we highlight the fundamental drug delivery systems and their mathematical foundations and discuss the physiological barriers to drug delivery. We review the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The latest developments in polymers capable of molecular recognition or directing intracellular delivery are surveyed to illustrate areas of research advancing the frontiers of drug delivery.

Polymers for Drug Delivery Systems

Complex formation between PDMAAm as a hydrogen-bonding acceptor and PAAc as a hydrogen-bonding donor, the temperature dependence of the equilibrium swelling for IPN hydrogels composed of PDMAAm and PAAc, and changes in ketoprofen release of these IPN hydrogels were investigated. Interpolymer complexes between PDMAAm and PAAc were very stable at 70°C in aqueous solution. Dissociation temperatures of the complex between poly(DMAAm-co-AAm) and PAAc shifted to higher values with increasing DMAAm content. These IPNs composed of poly(DMAAm-co-AAm) and PAAc showed limited swelling ratios between their swelling transition temperatures and lower swelling ratios above these transition temperatures. Transition temperatures shift to higher values with increasing DMAAm content

Temperature-Responsive Interpenetrating Polymer Networks Constructed with Poly(Acrylic Acid) and Poly(N,N-Dimethylacrylamide)

Thermo-responsive swelling and drug release switching of interpenetrating polymer networks composed of poly(acrylamide-co-butyl methacrylate) and poly (acrylic acid)

Interpenetrating polymer networks (IPNs) composed of poly(acrylamide(AAm)-co-butyl methacrylate (BMA)) and poly(acrylic acid) (PAAc) demonstrate positive swelling changes with an abrupt transition as temperature increases. Temperature-modulated controlled drug release using swelling-shrinking responses of the hydrogels as on-off switches for drug release is reported. The IPNs demonstrate “on” release at higher temperatures. When changing from higher to lower temperatures, an immediate pulsatile drug release is observed followed by a nearly complete “off” state of drug release. The drastic increase of drug release rate is due to mechanical squeezing by a shrinking gel surface layer of the IPNs in response to decreasing temperature. The following decrease of drug release is due to a subsequent formation of a dense layer of polymer at the IPN surface.

/pdf/drug-release-off-behavior-and-deswelling-kinetics-of-thermo-3jnzr7rrv9.pdf

Drug Release OFF Behavior and Deswelling Kinetics of Thermo-Responsive IPNs Composed of Poly(acrylamide- co -butyl methacrylate) and Poly(acrylic acid)

Regulation of temperature‐response swelling behavior of interpenetrating polymer networks composed of hydrogen bonding polymers

The optical filter of the present invention is provided with a near infrared light absorption layer that contains a component composed of copper ions and a phosphoric ester compound expressed by the following Formula (10), in which the phosphorus atom content in the near infrared light absorption layer is 0.4 to 1.3 mol per mole of copper ions, and the copper ion content in the near infrared light absorption layer is 2 to 60 wt %. Thus keeping the phosphorus atom and copper ion content within specific ranges results in good near infrared light absorption and in improved moisture resistance whereby devitrification caused by whitening is suppressed

Hiroki Katono

Papers

Temperature-Responsive Interpenetrating Polymer Networks Constructed with Poly(Acrylic Acid) and Poly(N,N-Dimethylacrylamide)

Thermo-responsive swelling and drug release switching of interpenetrating polymer networks composed of poly(acrylamide-co-butyl methacrylate) and poly (acrylic acid)

Drug Release OFF Behavior and Deswelling Kinetics of Thermo-Responsive IPNs Composed of Poly(acrylamide- co -butyl methacrylate) and Poly(acrylic acid)

Regulation of temperature‐response swelling behavior of interpenetrating polymer networks composed of hydrogen bonding polymers

Optical filter and process for producing the same