H
Hiromi Muramatsu
Researcher at University of Pennsylvania
Publications - 47
Citations - 5935
Hiromi Muramatsu is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 17, co-authored 27 publications receiving 3487 citations. Previous affiliations of Hiromi Muramatsu include Pennsylvania State University.
Papers
More filters
Journal ArticleDOI
Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine
Hiromi Muramatsu,Kieu Lam,Csaba Bajusz,Dorottya Laczkó,Katalin Karikó,Petra Schreiner,Alan D. Martin,Peter Lutwyche,James Heyes,Norbert Pardi +9 more
TL;DR: In this article , the physicochemical properties of the lyophilized material do not significantly change for 12 weeks after storage at room temperature and for at least 24 weeks after 4°C.
Journal ArticleDOI
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
Claudia P. Arevalo,Marcus J. Bolton,Valerie Le Sage,Naiqing Ye,Colleen Furey,Hiromi Muramatsu,Mohamad-Gabriel Alameh,Norbert Pardi,E. M. Drapeau,Kaela Parkhouse,Tyler A. Garretson,J. S. Morris,Louise H. Moncla,Ying K. Tam,Steven H.Y. Fan,Seema S. Lakdawala,Drew Weissman,Scott E. Hensley +17 more
TL;DR: This article developed a nucleoside-modified messenger RNA (mRNA)lipid nanoparticle vaccine encoding hemagglutinin antigens from all 20 known influenza A virus subtypes and influenza B virus lineages.
Journal ArticleDOI
Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs.
István Tombácz,Dorottya Laczkó,Hamna Shahnawaz,Hiromi Muramatsu,Ambika Natesan,Amir Yadegari,Tyler E. Papp,Mohamad-Gabriel Alameh,Vladimir V. Shuvaev,Barbara L. Mui,Ying K. Tam,Vladimir R. Muzykantov,Norbert Pardi,Drew Weissman,Hamideh Parhiz +14 more
TL;DR: In this article, the authors reported that conjugating CD4 antibody to LNPs enables specific targeting and mRNA interventions to CD4+ cells, including T lymphocytes, and demonstrated that the specific and efficient targeting and transfection of mRNA to T cells established in this study provides a platform technology for immunotherapy of devastating conditions and HIV cure.
Journal ArticleDOI
mRNA-1273 but not BNT162b2 induces antibodies against polyethylene glycol (PEG) contained in mRNA-based vaccine formulations
Juan Manuel Carreño,Gagandeep Singh,J. Tcheou,Komal Srivastava,C. Gleason,Hiromi Muramatsu,Parnavi Desai,Judith A. Aberg,Rachel L Miller,P. study group,Norbert Pardi,Viviana Simon,Florian Krammer +12 more
TL;DR: In this article , the authors determined if any of the components of mRNA-1273 or BNT162b2 formulations elicited PEG-specific antibody responses in serum by enzyme linked immunosorbent assay (ELISA).
Journal ArticleDOI
Electrical Forepaw Stimulation During Reversible Forebrain Ischemia Decreases Infarct Volume
Mark G. Burnett,Tomokazu Shimazu,Tamas Szabados,Hiromi Muramatsu,John A. Detre,Joel H. Greenberg +5 more
TL;DR: Functional stimulation of ischemic tissue may decrease tissue damage and improve outcome from stroke, Although the precise mechanism of this effect remains to be determined, functional stimulation could readily be translated to clinical practice.