S
Seema S. Lakdawala
Researcher at University of Pittsburgh
Publications - 81
Citations - 2846
Seema S. Lakdawala is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 22, co-authored 61 publications receiving 1747 citations. Previous affiliations of Seema S. Lakdawala include National Institute for Occupational Safety and Health & National Institutes of Health.
Papers
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Journal ArticleDOI
Airborne transmission of respiratory viruses.
Chia C. Wang,Chia C. Wang,Kimberly A. Prather,Josué Sznitman,Jose L. Jimenez,Jose L. Jimenez,Seema S. Lakdawala,Zeynep Tufekci,Linsey C. Marr,Linsey C. Marr +9 more
TL;DR: In this article, the authors discuss current evidence regarding the transmission of respiratory viruses by aerosols-how they are generated, transported, and deposited, as well as the factors affecting the relative contributions of droplet-spray deposition versus aerosol inhalation as modes of transmission.
Journal ArticleDOI
Mechanistic insights into the effect of humidity on airborne influenza virus survival, transmission and incidence.
TL;DR: This perspective article re-evaluate studies of influenza virus survival in aerosols, transmission in animal models and influenza incidence to show that the combination of temperature and RH is equally valid as AH as a predictor, and presents a mechanistic explanation based on droplets evaporation and its impact on droplet physics and chemistry for why RH is more likely than AH to modulate virus survival and transmission.
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Eurasian-origin gene segments contribute to the transmissibility, aerosol release, and morphology of the 2009 pandemic H1N1 influenza virus.
Seema S. Lakdawala,Elaine W. Lamirande,Amorsolo L. Suguitan,Weijia Wang,Celia Santos,Leatrice Vogel,Yumiko Matsuoka,William G. Lindsley,Hong Jin,Kanta Subbarao +9 more
TL;DR: It is demonstrated that the release of influenza viral RNA-containing particles into the air correlates with increased NA activity and the pleomorphic phenotype of the pH1N1 virus is dependent upon the Eurasian-origin gene segments, suggesting a link between transmission and virus morphology.
Journal ArticleDOI
Influenza Virus Infectivity Is Retained in Aerosols and Droplets Independent of Relative Humidity.
Karen A. Kormuth,Kaisen Lin,Aaron J. Prussin,Eric P. Vejerano,Andrea J. Tiwari,Steve S Cox,Michael M. Myerburg,Seema S. Lakdawala,Linsey C. Marr +8 more
TL;DR: In contrast to previously published reports, sustained infectivity of aerosolized influenza viruses in respiratory mucus over a wide-range of relative humidity conditions is detected, indicating a risk of airborne transmission in a broad range of environments.
Journal ArticleDOI
The soft palate is an important site of adaptation for transmissible influenza viruses
Seema S. Lakdawala,Seema S. Lakdawala,Akila Jayaraman,Rebecca A. Halpin,Elaine W. Lamirande,Angela R. Shih,Timothy B. Stockwell,Xudong Lin,Ari Simenauer,Christopher T. Hanson,Leatrice Vogel,Myeisha Paskel,Mahnaz Minai,Ian N. Moore,Marlene Orandle,Marlene Orandle,Suman R. Das,David E. Wentworth,David E. Wentworth,Ram Sasisekharan,Kanta Subbarao +20 more
TL;DR: It is demonstrated that the ferret soft palate, a tissue not normally sampled in animal models of influenza, rapidly selects for transmissible influenza A viruses with human receptor (α2,6-linked sialic acids) preference.