M
Masanori Utsuyama
Researcher at Tokyo Medical and Dental University
Publications - 97
Citations - 4429
Masanori Utsuyama is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 33, co-authored 97 publications receiving 4271 citations. Previous affiliations of Masanori Utsuyama include University of Tokushima.
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Journal ArticleDOI
Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor.
Atsuko Yanagisawa-Miwa,Yasumi Uchida,Fumitaka Nakamura,Takanobu Tomaru,Hideaki Kido,Takeshi Kamijo,Tsuneaki Sugimoto,Kazuhiko Kaji,Masanori Utsuyama,Chieri Kurashima,Hideki Ito +10 more
TL;DR: In a canine experimental myocardial infarct model, intracoronary injection of basic fibroblast growth factor (bFGF) improved cardiac systolic function and reducedinfarct size, suggesting the angiogenic action of bFGF might lead to a reduction in infarCT size.
Journal ArticleDOI
Bcl11b is required for differentiation and survival of alphabeta T lymphocytes.
Yuichi Wakabayashi,Hisami Watanabe,Jun Inoue,Naoki Takeda,Jun Sakata,Yukio Mishima,Jiro Hitomi,Takashi Yamamoto,Masanori Utsuyama,Ohtsura Niwa,Shinichi Aizawa,Ryo Kominami +11 more
TL;DR: The Bcl11b−/− thymocytes showed unsuccessful recombination of Vβ to Dβ and lacked the pre–T cell receptor (TCR) complex on the cell surface, owing to the absence of Tcrb mRNA expression, which suggests that B cl11b is a key regulator of both differentiation and survival during thymocyte development.
Journal ArticleDOI
Differential age-change in the numbers of CD4+CD45RA+ and CD4+CD29+ T cell subsets in human peripheral blood.
Masanori Utsuyama,Katsuiku Hirokawa,Chieri Kurashima,Makiko Fukayama,Takashi Inamatsu,Kenshi Suzuki,Wataru Hashimoto,Kazuto Sato +7 more
TL;DR: The most interesting finding was a contrasting age-change in two subsets of CD4+ T cells; i.e. a subset of suppressor inducer T cells (CD4+CD45RA+ naive cells) decreased with age, while a subset that showed an increase in numbers with age.
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Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus.
TL;DR: The presence of multiple RANKL-RANK pathways suggests a more complicated RANKl-Rank system for osteoclastogenesis or T cell differentiation than previously thought.
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Prostaglandin D2 Plays an Essential Role in Chronic Allergic Inflammation of the Skin via CRTH2 Receptor
Takahiro Satoh,Rie Moroi,Kosuke Aritake,Yoshihiro Urade,Yasumasa Kanai,Koji Sumi,Hiroo Yokozeki,Hiroyuki Hirai,Kinya Nagata,Toshifumi Hara,Masanori Utsuyama,Katsuiku Hirokawa,Kazuo Sugamura,Kiyoshi Nishioka,Masataka Nakamura +14 more
TL;DR: In models of chronic contact hypersensitivity induced by repeated hapten application, CRTH2 deficiency resulted in a reduction by approximately half of skin responses and low levels of serum IgE production, which indicates that the PGD2-CRTH2 system plays a significant role in chronic allergic skin inflammation.