H
Hajime Karasuyama
Researcher at Tokyo Medical and Dental University
Publications - 240
Citations - 21865
Hajime Karasuyama is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Immunoglobulin E & Basophil. The author has an hindex of 65, co-authored 231 publications receiving 20535 citations. Previous affiliations of Hajime Karasuyama include Tokyo University of Science & Institute of Medical Science.
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Journal ArticleDOI
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
Keisuke Kuida,Timothy S. Zheng,Songqing Na,Chia-Yi Kuan,Di Yang,Hajime Karasuyama,Pasko Rakic,Richard A. Flavell +7 more
TL;DR: CPP32 is shown to play a critical role during morphogenetic cell death in the mammalian brain during embryonic day 12, resulting in a variety of hyperplasias and disorganized cell deployment.
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Reduced Apoptosis and Cytochrome c-Mediated Caspase Activation in Mice Lacking Caspase 9
Keisuke Kuida,Tarik F. Haydar,Chia-Yi Kuan,Yong Gu,Choji Taya,Hajime Karasuyama,Michael S.-S. Su,Pasko Rakic,Richard A. Flavell +8 more
TL;DR: Results indicate that Casp9 is a critical upstream activator of the caspase cascade in vivo, as indicated by the absence of Casp3-like cleavage and the restoration of cytochrome c-mediated cleavage after addition of in vitro-translated Casp 9.
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Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors
Hajime Karasuyama,Fritz Melchers +1 more
TL;DR: Mouse cell lines of different lineages have been established which constitutively secrete large quantities of recombinant mouse interleukins, and an existing bovine papilloma virus‐based expression vector was modified to allow transformed X63Ag8‐653 myeloma cells, NIH 3T3 fibroblasts and C127 mammary tumor cells to stably carry multiple copies of the vector.
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Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response
Eric R. Fearon,Drew M. Pardoll,Toshiuki Itaya,Paul Golumbek,Hyam I. Levitsky,Jonathan W. Simons,Hajime Karasuyama,Bert Vogelstein,Philip Frost +8 more
TL;DR: These findings demonstrate that the failure of an effective antitumor immune response may be primarily due to a helper arm deficiency of the immune system rather than a paucity of tumor-specific cytotoxic effector cells and outline a novel strategy for augmenting tumor immunity.
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Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
Yoshiyuki Minegishi,Masako Saito,Shigeru Tsuchiya,Ikuya Tsuge,Hidetoshi Takada,Toshiro Hara,Nobuaki Kawamura,Tadashi Ariga,Srdjan Pasic,Oliver Stojkovic,Ayse Metin,Hajime Karasuyama +11 more
TL;DR: It is shown that dominant-negative mutations in the human signal transducer and activator of transcription 3 (STAT3) gene result in the classical multisystem HIES, highlighting the multiple roles played by STAT3 in humans, and underline the critical involvement of multiple cytokine pathways in the pathogenesis of HIES.