Hiroshi Katayama

TL;DR: In this article, the authors identify five different mutations in RAF1 in ten individuals with Noonan syndrome; those with any of four mutations causing changes in the CR2 domain of RAF1 had hypertrophic cardiomyopathy (HCM), whereas affected individuals with mutations leading to changes in CR3 domain did not.

TL;DR: Whether chymase is involved in angiotensin (Ang) II-induced AAA development in apolipoprotein E (apoE)-deficient mice is determined and the severity and luminal area of the AAAs in the Ang II-treated vehicle group were significantly suppressed by NK3201 treatment.

TL;DR: The increases in vascular Ang II-forming activities were involved in the progression of AAA after stopping the Ang II infusion, and significantly attenuated aortic diameter expansion.

TL;DR: Acute coronary syndrome occurred in 2 young adults who had a history of Kawasaki disease, but few other coronary risk factors, and was probably caused by accelerated atherosclerosis at the site without aneurysm as it seemed to be 'normal' on arteriography.

TL;DR: Angiotensin II-forming chymase may play a role in the proliferation of the medial layer in the lung arterioles of monocrotaline-induced pulmonary hypertensive rats and the effects of an angiotens in II receptor blocker on vascular remodeling are observed.