J
Jun Muneuchi
Researcher at Kyushu University
Publications - 90
Citations - 929
Jun Muneuchi is an academic researcher from Kyushu University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 12, co-authored 69 publications receiving 814 citations.
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Journal ArticleDOI
Germline gain-of-function mutations in RAF1 cause Noonan syndrome
M. Abdur Razzaque,Tsutomu Nishizawa,Yuta Komoike,Yuta Komoike,Hisato Yagi,Michiko Furutani,Ryunosuke Amo,Ryunosuke Amo,Mitsuhiro Kamisago,Kazuo Momma,Hiroshi Katayama,Masao Nakagawa,Yuko Fujiwara,Masaki Matsushima,Katsumi Mizuno,Mika Tokuyama,Hamao Hirota,Jun Muneuchi,Toru Higashinakagawa,Rumiko Matsuoka +19 more
TL;DR: In this article, the authors identify five different mutations in RAF1 in ten individuals with Noonan syndrome; those with any of four mutations causing changes in the CR2 domain of RAF1 had hypertrophic cardiomyopathy (HCM), whereas affected individuals with mutations leading to changes in CR3 domain did not.
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Pulmonary hypertension in patients with congenital portosystemic venous shunt: a previously unrecognized association.
Takuro Ohno,Jun Muneuchi,Kenji Ihara,Tetsuji Yuge,Yoshiaki Kanaya,Shigeo Yamaki,Toshiro Hara +6 more
TL;DR: This study demonstrated thromboembolic pulmonary arterial hypertension to be a crucial complication in congenital portosystemic venous shunt, and this pathologic state may be latently present in patients with pulmonary arterIAL hypertension of unknown etiology.
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Outcomes of cardiac surgery in trisomy 18 patients
Jun Muneuchi,Junko Yamamoto,Yasuhiko Takahashi,Mamie Watanabe,Tetsuji Yuge,Takuro Ohno,Yutaka Imoto,Akira Sese,Kunitaka Joo +8 more
TL;DR: Cardiac surgery contributed to increased survival rate but not the rate of discharge alive in trisomy 18 patients, and the indication of cardiac surgery should be carefully individualised to improve the quality of life intrisomy18 patients and concerned surrounding people.
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Genetic analysis of MMP gene polymorphisms in patients with Kawasaki disease
Kazuyuki Ikeda,Kenji Ihara,Kenichiro Yamaguchi,Jun Muneuchi,Takuro Ohno,Yumi Mizuno,Toshiro Hara +6 more
TL;DR: The genetic evaluation by association study demonstrated that the MMP-13 gene, at least in part, contributed to the development of CALs in KD.
Journal ArticleDOI
Cardiovascular Complications Associated with Chronic Active Epstein–Barr Virus Infection
Jun Muneuchi,Shouichi Ohga,Masataka Ishimura,Kazuyuki Ikeda,Kenichiro Yamaguchi,Akihiko Nomura,Hidetoshi Takada,Yasunobu Abe,Toshiro Hara +8 more
TL;DR: Among CAEBV patients, CAL was the most common cardiac complication and could not be controlled without the eradication of EBV-infected T- and NK-cells.