H
Hiroshi Kitagawa
Researcher at Kobe Pharmaceutical University
Publications - 259
Citations - 11912
Hiroshi Kitagawa is an academic researcher from Kobe Pharmaceutical University. The author has contributed to research in topics: Chondroitin sulfate & Chondroitin. The author has an hindex of 54, co-authored 259 publications receiving 10667 citations. Previous affiliations of Hiroshi Kitagawa include Johns Hopkins University & Cytel.
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Journal ArticleDOI
Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate
Kazuyuki Sugahara,Tadahisa Mikami,Toru Uyama,Souhei Mizuguchi,Kazuya Nomura,Hiroshi Kitagawa +5 more
TL;DR: Surprisingly, nonsulfated chondroitin is indispensable in the morphogenesis and cell division of Caenorhabditis elegans, as revealed by RNA interference experiments of the recently cloned chondDetroitin synthase gene and by the analysis of mutants of squashed vulva genes.
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Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans.
TL;DR: Recent cDNA cloning of the glycosyltransferases involved in the synthesis of the sulfated glycosaminoglycan sidechains of proteoglycans has provided important clues to answering long-standing questions concerning the mechanisms of both chain polymerization and the biosynthetic sorting of glucosaminoglycANS.
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Biosynthesis and function of chondroitin sulfate.
Tadahisa Mikami,Hiroshi Kitagawa +1 more
TL;DR: This work focuses on recent advances in the study of enzymatic regulatory pathways for CS biosynthesis including successive modification/degradation, distinct CS functions, and disease phenotypes that have been revealed by perturbation of the respective enzymes in vitro and in vivo.
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Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity.
Barbara A. Sorg,Sabina Berretta,Jordan M. Blacktop,James W. Fawcett,Hiroshi Kitagawa,Jessica C. F. Kwok,Marta Miquel +6 more
TL;DR: The focus is on how a major component of PNNs, chondroitin sulfate proteoglycans, control plasticity, and on the role of Pnns in memory in normal aging, in a tauopathy model of Alzheimer's disease, and in drug addiction.
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Persistent cortical plasticity by upregulation of chondroitin 6-sulfation
TL;DR: The results indicate that the critical period for cortical plasticity is regulated by the 4S/6S ratio of CSPGs, which determines the maturation of parvalbumin-expressing interneurons.