Hiroshi Nagase

TL;DR: It is shown that B5-I neurons are innervated by menthol-, capsaicin-, and mustard oil-responsive sensory neurons and are required for the inhibition of itch by Menthol, suggesting that kappa opioids may be a broadly effective therapy for pathological itch.

TL;DR: MRGPRX2 is a unique atypical opioid-like receptor important for modulating mast cell degranulation, which can now be specifically modulated with ZINC-3573, which represents a potent MRG PRX2-selective agonist, showing little activity against 315 other GPCRs and 97 representative kinases.

TL;DR: The effects of the kappa-opioid receptor agonist, TRK-820, (-)-17-(cyclopropylmethyl)-3, 14beta-dihydroxy-4, 5alpha-epoxy-6beta-[N-methyl-trans-3-(3-furyl) acrylamido] morphinan hydrochloride, on the itch sensation were compared with those of histamine H1 receptor antagonists, using the mouse pruritogen-induced scratching model as discussed by the authors.

TL;DR: It is possible that delta-opioid-receptor agonists might be novel and potent antidepressants that also have anxiolytic-like effects and may play an important role in the regulation of emotional responses.

TL;DR: It is suggested that κ-agonists suppress the morphine-induced place preference, and that activation of λ-opioid receptors could suppress the reinforcing effects of morphine which may be induced by enhanced DA transmission in the mesolimbic DA system.