H
Hiroyuki Iwai
Researcher at Daikin
Publications - 23
Citations - 466
Hiroyuki Iwai is an academic researcher from Daikin. The author has contributed to research in topics: Trifluoromethyl & Oral administration. The author has an hindex of 8, co-authored 23 publications receiving 422 citations. Previous affiliations of Hiroyuki Iwai include Kyoto University.
Papers
More filters
Journal ArticleDOI
Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months.
John L. Butenhoff,Giovanni Costa,Cliff Elcombe,David G. Farrar,Kristin Hansen,Hiroyuki Iwai,Reinhard Jung,Gerald L. Kennedy,Paul H. Lieder,Geary W. Olsen,Peter J. Thomford +10 more
TL;DR: There were no APFO-related macroscopic or microscopic changes, changes in clinical chemistry, hormones, or urinalysis, or hematological effects, and effects that have been associated with the development of pancreatic and testicular toxicity in rats were not observed in this study.
Journal ArticleDOI
Evaluation of the chronic toxicity and carcinogenicity of perfluorohexanoic acid (PFHxA) in Sprague-Dawley rats
James E. Klaunig,Motoki Shinohara,Hiroyuki Iwai,Christopher P. Chengelis,Jeannie B. Kirkpatrick,Zemin Wang,Richard H. Bruner +6 more
TL;DR: While no difference in survival rates in males was seen, a dose-dependent decrease in survival in PFHxA-treated female rats was observed, and there was no evidence that PFHXA was tumorigenic in male or female SD rats at any of the dosage levels examined.
Journal ArticleDOI
Oral (Gavage) Combined Developmental and Perinatal/Postnatal Reproduction Toxicity Study of Ammonium Salt of Perfluorinated Hexanoic Acid in Mice:
Hiroyuki Iwai,Alan M. Hoberman +1 more
TL;DR: The maternal and reproductive no observable adverse effect level of PFHxA Ammonium Salt is 100 mg/kg/d, which is below the lower limit of quantization.
Journal ArticleDOI
90-day oral gavage toxicity study of 8-2 fluorotelomer alcohol in rats.
Gregory S. Ladics,Gerald L. Kennedy,John C. O'Connor,Nancy E. Everds,Linda A. Malley,Steven R. Frame,Shawn A. Gannon,Reinhard Jung,Thomas Roth,Hiroyuki Iwai,Seiji Shin-Ya +10 more
TL;DR: With the exception of hepatocellular necrosis in males at 125mg/kg and the increased incidence and severity of chronic progressive nephropathy in females at 125 mg/kg, all other changes showed evidence of reversibility, and the no-observed-adverse-effect level was 5 mg/ kg.
Journal ArticleDOI
Optical isomers of a new 2-nitroimidazole nucleoside analog (PR-350 series): Radiosensitization efficiency and toxicity
Natsuo Oya,Yuta Shibamoto,Keisuke Sasai,Toru Shibata,Rumi Murata,Takehisa Takagi,Hiroyuki Iwai,Toshimitsu Suzuki,Mitsuyuki Abe +8 more
TL;DR: Although PR-28 was the least toxic, its low sensitization efficiency does not warrant clinical trials and in vivo radiosensitizing activity differed among the four optical isomers, which appeared to be due, at least in part, to differences in lipophilicity.