Hisashi Wada

TL;DR: The results suggest that TNF has an essential homeostatic role in limiting the extent and duration of an inflammatory process-i.e., an anti-inflammatory function.

TL;DR: Depletion of FOXP3hi Treg cells from tumor tissues, which would augment antitumor immunity, could thus be used as an effective treatment strategy for CRCs and other cancers, whereas strategies that locally increase the population ofFOXP3lo non-Treg cells could be used to suppress or prevent tumor formation.

TL;DR: Combined use of KW-0761 to deplete FoxP3+ Tregs with other immunotherapies, such as cancer vaccines or checkpoint inhibitors, is a promising approach to augment immune responses.

TL;DR: T cell immunomonitoring and tumor responses in patients vaccinated with a complex of cholesterol-bearing hydrophobized pullulan and NY-ESO-1 protein showed an increase in the CD4 and CD8 T cell response, and prostate-specific antigen (PSA) values stabilized during the course of vaccination.

TL;DR: This study suggests that the frequency of eTreg cells in TILs could be a biomarker for stratifying clinical responses to RAM-containing therapies, and proposes that RAM may be employed as an immuno-modulator in combination with immune checkpoint blockade.