H
Hidetoshi Morita
Researcher at Okayama University
Publications - 165
Citations - 14901
Hidetoshi Morita is an academic researcher from Okayama University. The author has contributed to research in topics: Gut flora & Whole genome sequencing. The author has an hindex of 40, co-authored 160 publications receiving 11983 citations. Previous affiliations of Hidetoshi Morita include University of Tokyo & Azabu University.
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Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Koji Atarashi,Takeshi Tanoue,Kenshiro Oshima,Wataru Suda,Yuji Nagano,Hiroyoshi Nishikawa,Shinji Fukuda,Takuro Saito,Seiko Narushima,Koji Hase,Sangwan Kim,Joëlle V. Fritz,Paul Wilmes,Satoshi Ueha,Kouji Matsushima,Hiroshi Ohno,Bernat Olle,Shimon Sakaguchi,Tadatsugu Taniguchi,Hidetoshi Morita,Masahira Hattori,Kenya Honda +21 more
TL;DR: Using a rational approach to isolate CD4+FOXP3+ regulatory T (Treg)-cell-inducing bacterial strains from the human indigenous microbiota may allow for tailored therapeutic manipulation of human immune disorders.
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Bifidobacteria can protect from enteropathogenic infection through production of acetate
Shinji Fukuda,Hidehiro Toh,Koji Hase,Kenshiro Oshima,Yumiko Nakanishi,Kazutoshi Yoshimura,Toru Tobe,Julie M. Clarke,David L. Topping,Tohru Suzuki,Todd D. Taylor,Kikuji Itoh,Jun Kikuchi,Jun Kikuchi,Hidetoshi Morita,Masahira Hattori,Hiroshi Ohno,Hiroshi Ohno +17 more
TL;DR: It is proposed that acetate produced by protective bifidobacteria improves intestinal defence mediated by epithelial cells and thereby protects the host against lethal infection.
Journal ArticleDOI
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Shin Yoshimoto,Tze Mun Loo,Tze Mun Loo,Koji Atarashi,Hiroaki Kanda,Seidai Sato,Seiichi Oyadomari,Yoichiro Iwakura,Kenshiro Oshima,Hidetoshi Morita,Masahira Hattori,Kenya Honda,Yuichi Ishikawa,Eiji Hara,Naoko Ohtani +14 more
TL;DR: It is shown that senescence-associated secretory phenotype (SASP) has crucial roles in promoting obesity-associated hepatocellular carcinoma (HCC) development in mice, and a similar pathway may contribute to at least certain aspects of obesity- associated HCC development in humans as well.
Journal ArticleDOI
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells
Koji Atarashi,Takeshi Tanoue,Minoru Ando,Nobuhiko Kamada,Yuji Nagano,Seiko Narushima,Wataru Suda,Wataru Suda,Akemi Imaoka,Hiromi Setoyama,Takashi Nagamori,Eiji Ishikawa,Tatsuichiro Shima,Taeko Hara,Shoichi Kado,Toshi Jinnohara,Hiroshi Ohno,Takashi Kondo,Kiminori Toyooka,Eiichiro Watanabe,Shin ichiro Yokoyama,Shunji Tokoro,Hiroshi Mori,Yurika Noguchi,Hidetoshi Morita,Ivaylo I. Ivanov,Tsuyoshi Sugiyama,Gabriel Núñez,J. Gray Camp,Masahira Hattori,Masahira Hattori,Yoshinori Umesaki,Kenya Honda +32 more
TL;DR: It is shown that adhesion of microbes to intestinal epithelial cells (ECs) is a critical cue for Th17 induction, and a mixture of 20 bacterial strains, which were selected and isolated from fecal samples of a patient with ulcerative colitis on the basis of their ability to cause a robust induction of Th17 cells in the mouse colon, exhibited EC-adhesive characteristics.
Comparative Metagenomics Revealed Commonly Enriched Gene Sets in
S. Ishikawa,Yoshitoshi Ogura,Mika Yoshimura,Hajime Okumura,E. Cho,Yoshikazu Kawai,Ken Kurokawa,Toshiaki Itoh,Tomomi Kuwahara,Kenshiro Oshima,Hidehiro Toh,Atsushi Toyoda,Hideto Takami,Hidetoshi Morita,Vineet K. Sharma,Tulika P. Srivastava,Todd D. Taylor,Hideki Noguchi,H. Mori,D. S. Ehrlich +19 more
TL;DR: A conjugative transposon family explosively amplified in human gut microbiomes is discovered, which strongly suggests that the intestine is a ‘hot spot’ for horizontal gene transfer between microbes.