Naganari Ohkura

TL;DR: For example, the authors mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body.

TL;DR: It is shown that the transcription factor AML1 (acute myeloid leukaemia 1)/Runx1 (Runt-related transcription factor 1), which is crucially required for normal haematopoiesis including thymic T-cell development, activates IL-2 and IFN-γ gene expression in conventional CD4+ T cells through binding to their respective promoters.

TL;DR: Understanding how epigenetic alterations and Foxp3 expression coordinately control Treg-cell-specific gene regulation will enable better control of immune responses by targeting the generation and maintenance of Treg cells.

TL;DR: It is shown that Treg cell development was achieved by the combination of two independent processes, i.e., the expression of Foxp3 and the establishment of TReg cell-specific CpG hypomethylation pattern, and those T cells in which the two events have concurrently occurred are developmentally set into the T Reg cell lineage.

TL;DR: Depletion of FOXP3hi Treg cells from tumor tissues, which would augment antitumor immunity, could thus be used as an effective treatment strategy for CRCs and other cancers, whereas strategies that locally increase the population ofFOXP3lo non-Treg cells could be used to suppress or prevent tumor formation.