H
Hiu-Ki R Tran
Researcher at McMaster University
Publications - 4
Citations - 1647
Hiu-Ki R Tran is an academic researcher from McMaster University. The author has contributed to research in topics: Resistome & Macrolide Antibiotics. The author has an hindex of 3, co-authored 4 publications receiving 603 citations.
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Journal ArticleDOI
CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database
Brian Alcock,Amogelang R. Raphenya,Tammy T. Y. Lau,Kara K. Tsang,Mégane Bouchard,Arman Edalatmand,William Huynh,Anna-Lisa V. Nguyen,Annie A. Cheng,Sihan Liu,Sally Y. Min,Anatoly Miroshnichenko,Hiu-Ki R Tran,Rafik El Werfalli,Jalees A. Nasir,Martins Oloni,David Speicher,Alexandra Florescu,Bhavya Singh,Mateusz Faltyn,Anastasia Hernández-Koutoucheva,Arjun N. Sharma,Emily Bordeleau,Andrew C. Pawlowski,Haley L. Zubyk,Damion M. Dooley,Emma Griffiths,Finlay Maguire,Geoffrey L. Winsor,Robert G. Beiko,Fiona S. L. Brinkman,William W. L. Hsiao,William W. L. Hsiao,Gary Van Domselaar,Gary Van Domselaar,Andrew G. McArthur +35 more
TL;DR: A new Resistomes & Variants module provides analysis and statistical summary of in silico predicted resistance variants from 82 pathogens and over 100 000 genomes, able to summarize predicted resistance using the information included in CARD, identify trends in AMR mobility and determine previously undescribed and novel resistance variants.
Journal ArticleDOI
An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp.
Shehryar Ahmad,Boyuan Wang,Walker,Hiu-Ki R Tran,Peter J. Stogios,Alexei Savchenko,Alexei Savchenko,Robert A. Grant,Andrew G. McArthur,Michael T. Laub,John C. Whitney +10 more
TL;DR: A previously undescribed mechanism for interbacterial antagonism is revealed and a physiological role for the metabolite (p)ppApp in bacteria is demonstrated in bacteria.
Journal ArticleDOI
Bacterial type VII secretion: An important player in host-microbe and microbe-microbe interactions.
TL;DR: In this article, the authors compare the molecular architectures and substrate repertoires of the well-studied mycobacterial Type VII secretion systems (T7SSa) to that of recently characterized T7SSb pathways and highlight how these differences may explain the observed biological functions of this understudied protein export machine.
Journal ArticleDOI
Overcoming Acquired and Native Macrolide Resistance with Bicarbonate.
Maya A. Farha,Craig R. MacNair,Lindsey A. Carfrae,Sara S. El Zahed,Michael J. Ellis,Hiu-Ki R Tran,Andrew G. McArthur,Eric D. Brown +7 more
TL;DR: The findings suggest that macrolide resistance, observed in the clinical microbiology laboratory using standard culturing techniques, is a poor predictor of efficacy in the clinic and that observed resistance should not necessarily hamper the use of macrolides.