H
Ho Sup Yoon
Researcher at Nanyang Technological University
Publications - 135
Citations - 9331
Ho Sup Yoon is an academic researcher from Nanyang Technological University. The author has contributed to research in topics: FKBP & Protein structure. The author has an hindex of 34, co-authored 134 publications receiving 8718 citations. Previous affiliations of Ho Sup Yoon include Kyung Hee University & University of Chicago.
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Journal ArticleDOI
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.
Michael Sattler,Heng Liang,David G. Nettesheim,Robert P. Meadows,John E. Harlan,Matthias Eberstadt,Ho Sup Yoon,Suzanne B. Shuker,Brian S. Chang,Andy J. Minn,Craig B. Thompson,Stephen W. Fesik +11 more
TL;DR: The structure and binding affinities of mutant Bak peptides indicate that the Bak peptide adopts an amphipathic α helix that interacts with Bcl-xL through hydrophobic and electrostatic interactions.
Journal ArticleDOI
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
Steven W. Muchmore,Michael Sattler,Heng Liang,Robert P. Meadows,John E. Harlan,Ho Sup Yoon,David G. Nettesheim,Brian S. Chang,Brian S. Chang,Craig B. Thompson,Craig B. Thompson,Sui-Lam Wong,Shi-Chung Ng,Stephen W. Fesik +13 more
TL;DR: The arrangement of the α-helices in Bcl-xL is reminiscent of the membrane translocation domain of bacterial toxins, in particular diphia toxin and the colicins, and may provide a clue to the mechanism of action of the B cl-2 family of proteins.
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Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.
TL;DR: It is reported that pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate and shown that the lipid-binding site is located at the lip of the β-barrel.
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Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer.
TL;DR: Cationic core–shell nanoparticles that were self-assembled from a biodegradable amphiphilic copolymer offer advantages over liposomes, as they are easier to fabricate, and are more readily subject to modulation of their size and degree of positive charge.
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Correction: Corrigendum: Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells
Seonghoon Kim,Hye Guk Ryu,Juhyun Lee,Joon Shin,Amaravadhi Harikishore,Hoe-Yune Jung,Ye Seul Kim,Ha-Na Lyu,Eun-Ji Oh,Nam-In Baek,Kwan-Yong Choi,Ho Sup Yoon,Kyong-Tai Kim +12 more
TL;DR: In this paper, the authors found that ursolic acid (UA) inhibits the catalytic activity of vaccine-related kinase 1 via direct binding to the protein domain of VRK1.