H
Hoa-Le Mai
Researcher at University of Nantes
Publications - 2
Citations - 106
Hoa-Le Mai is an academic researcher from University of Nantes. The author has contributed to research in topics: T cell & Interleukin-7 receptor. The author has an hindex of 2, co-authored 2 publications receiving 72 citations.
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Journal ArticleDOI
IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease.
Lyssia Belarif,Richard Danger,Laetitia Kermarrec,Véronique Nerrière-Daguin,Sabrina Pengam,Tony Durand,Caroline Mary,Elise Kerdreux,Vanessa Gauttier,Aneta Kucik,Virginie Thepenier,Jerome Martin,Christie Chang,Adeeb Rahman,Nina Salabert-Le Guen,Cécile Braudeau,Ahmed Abidi,Ahmed Abidi,Grégoire David,Florent Malard,Celine Takoudju,Bernard Martinet,Nathalie Gérard,Isabelle Neveu,Michel Neunlist,Emmanuel Coron,Thomas T. MacDonald,Pierre Desreumaux,Hoa-Le Mai,Stéphanie Le Bas-Bernardet,Jean-François Mosnier,Miriam Merad,Régis Josien,Sophie Brouard,Jean-Paul Soulillou,Gilles Blancho,Arnaud Bourreille,Philippe Naveilhan,Bernard Vanhove,Nicolas Poirier +39 more
TL;DR: Key transcripts of the IL-7 receptor (IL-7R) pathway are accumulated in inflamed colon tissues of severe CD and UC patients not responding to either immunosuppressive/corticosteroid, anti-TNF, or anti-α4β7 therapies, and point to IL- 7R as a relevant therapeutic target and potential biomarker to fill an unmet need in clinical IBD detection and treatment.
Journal ArticleDOI
IL-7 receptor blockade following T cell depletion promotes long-term allograft survival
Hoa-Le Mai,Françoise Boeffard,Julie Longis,Richard Danger,Bernard Martinet,Fabienne Haspot,Bernard Vanhove,Sophie Brouard,Jean-Paul Soulillou +8 more
TL;DR: The data suggest that IL-7R blockade following T cell depletion has potential as a robust, immunosuppressive therapy in transplantation.