B
Bernard Martinet
Researcher at University of Nantes
Publications - 18
Citations - 978
Bernard Martinet is an academic researcher from University of Nantes. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 11, co-authored 16 publications receiving 802 citations. Previous affiliations of Bernard Martinet include French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Myeloid-Derived Suppressor Cells Accumulate in Kidney Allograft Tolerance and Specifically Suppress Effector T Cell Expansion
Anne-Sophie Dugast,Thomas Haudebourg,Flora Coulon,Michèle Heslan,Fabienne Haspot,Nicolas Poirier,Romain Vuillefroy de Silly,Claire Usal,Helga Smit,Bernard Martinet,Pamela Thebault,Karine Renaudin,Bernard Vanhove +12 more
TL;DR: It is suggested that increased numbers of MDSC can inhibit alloreactive T cell proliferation in vivo and that these cells may participate in the NO-dependent maintenance phase of tolerance.
Journal ArticleDOI
Inducing CTLA-4–Dependent Immune Regulation by Selective CD28 Blockade Promotes Regulatory T Cells in Organ Transplantation
Nicolas Poirier,Agnes M. Azimzadeh,Tianshu Zhang,Nahzli Dilek,Caroline Mary,B.N. Nguyen,Xavier Tillou,G Wu,Karine Reneaudin,Jeremy Hervouet,Bernard Martinet,Flora Coulon,Emma Allain-Launay,Georges Karam,Jean-Paul Soulillou,Richard N. Pierson,Gilles Blancho,Bernard Vanhove +17 more
TL;DR: The Vanhove, Blancho, and Pierson labs aimed to block CD28 function directly in experiments on kidney and heart transplantation in baboons and monkeys, and showed that down-regulation of CD28 activity with an anti-CD28 monoclonal antibody inhibited rejection of organ transplants in rodents.
Journal ArticleDOI
Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors.
TL;DR: It is found that syngeneic aBMDCs, injected one day before transplantation, induced significant prolongation of heart allograft survival and decreased anti‐donor humoral and cellular responses, and these data suggest that SyngeneIC aBM DCs can modulate immune responses.
Journal ArticleDOI
Control of Transplant Tolerance and Intragraft Regulatory T Cell Localization by Myeloid-Derived Suppressor Cells and CCL5
Nahzli Dilek,Nicolas Poirier,Claire Usal,Claire Usal,Bernard Martinet,Bernard Martinet,Gilles Blancho,Gilles Blancho,Bernard Vanhove,Bernard Vanhove +9 more
TL;DR: The contribution of MDSC to the establishment of a graft-to-periphery CCL5 gradient in tolerant kidney allograft recipients, which controls recruitment of Treg to the graft where they likely contribute to maintaining tolerance, is highlighted.
Journal ArticleDOI
IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease.
Lyssia Belarif,Richard Danger,Laetitia Kermarrec,Véronique Nerrière-Daguin,Sabrina Pengam,Tony Durand,Caroline Mary,Elise Kerdreux,Vanessa Gauttier,Aneta Kucik,Virginie Thepenier,Jerome Martin,Christie Chang,Adeeb Rahman,Nina Salabert-Le Guen,Cécile Braudeau,Ahmed Abidi,Ahmed Abidi,Grégoire David,Florent Malard,Celine Takoudju,Bernard Martinet,Nathalie Gérard,Isabelle Neveu,Michel Neunlist,Emmanuel Coron,Thomas T. MacDonald,Pierre Desreumaux,Hoa-Le Mai,Stéphanie Le Bas-Bernardet,Jean-François Mosnier,Miriam Merad,Régis Josien,Sophie Brouard,Jean-Paul Soulillou,Gilles Blancho,Arnaud Bourreille,Philippe Naveilhan,Bernard Vanhove,Nicolas Poirier +39 more
TL;DR: Key transcripts of the IL-7 receptor (IL-7R) pathway are accumulated in inflamed colon tissues of severe CD and UC patients not responding to either immunosuppressive/corticosteroid, anti-TNF, or anti-α4β7 therapies, and point to IL- 7R as a relevant therapeutic target and potential biomarker to fill an unmet need in clinical IBD detection and treatment.