H
Hoi-Yun Chan
Researcher at The Chinese University of Hong Kong
Publications - 57
Citations - 4377
Hoi-Yun Chan is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Hepatitis B & HBeAg. The author has an hindex of 32, co-authored 55 publications receiving 3891 citations.
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Journal ArticleDOI
Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years
Vincent Wai-Sun Wong,Grace Lai-Hung Wong,Paul Cheung-Lung Choi,Anthony W.H. Chan,Mia Ka-Po Li,Hoi-Yun Chan,Angel Mei-Ling Chim,Jun Yu,Joseph J.Y. Sung,Henry Lik-Yuen Chan +9 more
TL;DR: Investigating disease progression in patients with different degrees of non-alcoholic fatty liver disease (NAFLD) activity found weight reduction is associated with non-progressive disease and fibrosis.
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Entecavir treatment reduces hepatic events and deaths in chronic hepatitis B patients with liver cirrhosis.
Grace Lai-Hung Wong,Henry Lik-Yuen Chan,Christy Wing-Hin Mak,Stanley King–Yeung Lee,Zoe Man–Yi Ip,Andrew Lam,Henry Wing–Hang Iu,Joyce May–Sum Leung,Jennifer Wing-Yan Lai,Angeline Oi-Shan Lo,Hoi-Yun Chan,Vincent Wai-Sun Wong +11 more
TL;DR: Entecavir therapy reduces the risks of hepatic events, HCC, liver‐related and all‐cause mortality of CHB patients with liver cirrhosis in 5 years, particularly among those who had maintained viral suppression.
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A longitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B.
Henry Lik-Yuen Chan,Vincent Wai-Sun Wong,Grace Lai-Hung Wong,Chi-Hang Tse,Hoi-Yun Chan,Joseph J.Y. Sung +5 more
TL;DR: HBsAg remained stable in HBeAg‐positive patients and tended to reduce slowly in H beAg‐negative patients, suggesting reduction of HBsAg for >1 log IU/mL could reflect improved immune control.
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Non-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers.
Jiayun Shen,Henry Lik-Yuen Chan,Grace Lai-Hung Wong,Paul Cheung-Lung Choi,Anthony W.H. Chan,Hoi-Yun Chan,Angel Mei-Ling Chim,David K.W. Yeung,Francis K.L. Chan,Jean Woo,Jun Yu,Winnie C.W. Chu,Vincent Wai-Sun Wong +12 more
TL;DR: CK-18 is the most accurate biomarker for NAFLD and NASH and a two-step approach using CK-18 and FGF21 further improves the accuracy in diagnosing NASH.
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High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B.
Vincent Wai-Sun Wong,Jun Yu,Alfred S. L. Cheng,Grace Lai-Hung Wong,Hoi-Yun Chan,Eagle S. H. Chu,Enders K.O. Ng,Francis K.L. Chan,Joseph J.Y. Sung,Henry Lik-Yuen Chan +9 more
TL;DR: High serum IL‐6 level predates the development of HCC in chronic hepatitis B patients, and has moderate accuracy in predicting future cancer, which may assist clinicians in selecting high‐risk patients for HCC surveillance program.