Hong Lim Kim

TL;DR: It is suggested that autophagy deficiency and subsequent mitochondrial dysfunction promote Fgf21 expression, a hormone the authors consequently term a 'mitokine', and together these processes promote protection from diet-induced obesity and insulin resistance.

TL;DR: It is shown that mice with global haploinsufficiency of an essential autophagy gene (Atg7(+/-) mice) do not show metabolic abnormalities but develop diabetes when crossed with ob/ob mice, suggesting that systemic autophagic insufficiency could be a factor in the progression from obesity to diabetes.

TL;DR: This work investigates the role of autophagy in the obstructed kidney and contralateral kidney after UUO, a model of progressive renal fibrosis in the Obstructed kidney that is followed by compensatory cellular proliferation in the contralsateral kidney.

TL;DR: The data showed that autophagy in distal TEC plays a protective role in development of renal tubulointerstial fibrosis through regulating the expression of TGF-β an IL1-β after UUO.

TL;DR: The data suggest that kidney organoids derived from iPS cells may be transplantable but strategies to improve nephron differentiation and purity are required before they can be applied in humans as a therapeutic option.