H
Hongde Xu
Researcher at China Medical University (PRC)
Publications - 17
Citations - 283
Hongde Xu is an academic researcher from China Medical University (PRC). The author has contributed to research in topics: Carcinogenesis & Autophagy. The author has an hindex of 7, co-authored 13 publications receiving 150 citations.
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Journal ArticleDOI
ATM-CHK2-Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress.
Qiqiang Guo,Shan-Shan Wang,Shan-Shan Zhang,Hongde Xu,Xiaoman Li,Yi Guan,Fei Yi,Tingting Zhou,Bo Jiang,Ning Bai,Meng-Tao Ma,Zhuo Wang,Yanling Feng,Wendong Guo,Xuan Wu,Gui-Feng Zhao,Guangjian Fan,Shengping Zhang,Chuangui Wang,Longyue Cao,Brian P. O’Rourke,Shihui Liu,Ping-Yuan Wang,Shuai Han,Xiaoyu Song,Liu Cao +25 more
TL;DR: The results indicate that the ROS‐ATM‐CHK2‐Beclin 1‐autophagy axis serves as a physiological adaptation pathway that protects cells exposed to pathological conditions from stress‐induced tissue damage.
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Combined preconditioning and postconditioning provides synergistic protection against liver ischemic reperfusion injury.
TL;DR: It is suggested that in addition to individual preconditioning or postconditioning, the combination of these two treatments could reduce liver ischemia/reperfusion injury more effectively by increasing the activity of ROS scavengers and antioxidants.
Journal ArticleDOI
SIRT1 modulates cell cycle progression by regulating CHK2 acetylation−phosphorylation
Wenyu Zhang,Yanling Feng,Qiqiang Guo,Wendong Guo,Hongde Xu,Xiaoman Li,Fei Yi,Yi Guan,Nanxi Geng,Ping-Yuan Wang,Longyue Cao,Brian P. O’Rourke,Juhyeon Jo,Jiyun Kwon,Ruihong Wang,Xiaoyu Song,In Hye Lee,Liu Cao +17 more
TL;DR: It is suggested that CHK2 mediates the function of SIRT1 in cell cycle progression, and may provide new insights into modulating cellular homeostasis and maintaining genomic integrity in the prevention of aging and cancer.
Journal ArticleDOI
Protective effect of grape seed proanthocyanidins against liver ischemic reperfusion injury: particularly in diet-induced obese mice.
TL;DR: GSP could significantly reduce hepatic IRI by protecting hepatocyte function and increasing the activity of ROS scavengers, as well as decreasing cytokines levels, and combined GSP and postconditioning can provided synergistic protection.
Journal ArticleDOI
Atg7 inhibits Warburg effect by suppressing PKM2 phosphorylation resulting reduced epithelial-mesenchymal transition.
Yanling Feng,Jingwei Liu,Wendong Guo,Yi Guan,Hongde Xu,Qiqiang Guo,Xiaoyu Song,Fei Yi,Ting Liu,Wenyu Zhang,Xiang Dong,Longyue L Cao,Brian P. O’Rourke,Liu Cao +13 more
TL;DR: A molecular link between Atg7 and the Warburg effect is revealed, which may provide insight into novel strategies for cancer treatment and help clarify the role of autophagy in tumorigenesis.