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Xiaoman Li
Researcher at Chinese Ministry of Education
Publications - 27
Citations - 711
Xiaoman Li is an academic researcher from Chinese Ministry of Education. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 10, co-authored 17 publications receiving 529 citations. Previous affiliations of Xiaoman Li include University of Oklahoma Health Sciences Center.
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Journal ArticleDOI
PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
TL;DR: The reason why inhibition of the mTOR-complex pathway may serve as a compelling therapeutic target for the disease is explored, and update data of EFGR and PI3K/Akt/mTOR inhibitors in clinical trials is provided.
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α-Phenyl-N-tert-butylnitrone (PBN) Prevents Light-induced Degeneration of the Retina by Inhibiting RPE65 Protein Isomerohydrolase Activity
Nawajes A. Mandal,Gennadiy Moiseyev,Michael H. Elliott,Anne Kasus-Jacobi,Xiaoman Li,Hui Chen,Lixin Zheng,Olga Nikolaeva,Robert A. Floyd,Jian Xing Ma,Robert E. Anderson +10 more
TL;DR: PBN inhibition of RPE65 catalytic action may provide therapeutic benefit for retinal diseases, such as Stargardt disease and dry age-related macular degeneration, in which toxic byproducts of the visual cycle accumulate in retinal cells.
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Loss of Caveolin-1 Impairs Retinal Function Due to Disturbance of Subretinal Microenvironment
Xiaoman Li,Mark E. McClellan,Masaki Tanito,Philippe Garteiser,Rheal A. Towner,David Bissig,Bruce A. Berkowitz,Steven J. Fliesler,Michael L. Woodruff,Gordon L. Fain,David G. Birch,M. Suhaib Khan,John D. Ash,Michael H. Elliott +13 more
TL;DR: It is demonstrated that reduced retinal function resulting from Cav-1 ablation is not photoreceptor-intrinsic but rather involves impaired subretinal and/or RPE ion/fluid homeostasis.
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Ischemic Preconditioning Protects against Spinal Cord Ischemia-Reperfusion Injury in Rabbits by Attenuating Blood Spinal Cord Barrier Disruption
TL;DR: It is suggested that ischemic preconditioning attenuates the increase in blood spinal cord barrier permeability due to spinal cord I-R injury by preservation of tight junction protein ZO-1 and reducing MMP-9 and TNF-α expression.
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Caveolin-1 Increases Proinflammatory Chemoattractants and Blood–Retinal Barrier Breakdown but Decreases Leukocyte Recruitment in Inflammation
Xiaoman Li,Xiaowu Gu,Timothy M. Boyce,Min Zheng,Alaina M. Reagan,Hui Qi,Nawajes A. Mandal,Alex W. Cohen,Michelle C. Callegan,Daniel J.J. Carr,Michael H. Elliott +10 more
TL;DR: Cav-1 expression may enhance inflammatory signaling while at the same time supporting the physical properties of the BRB, and paradoxically modulates inflammatory signaling and leukocyte infiltration through distinct mechanisms.